Background. We analyzed the early and long-term quality of life changes occurring in 16 patients undergoing tailored combined surgery for stage I non-small-cell lung cancer (NSCLC) and severe emphysema. Methods. Mean age was 65 +/- 5 years. All patients had severe emphysema with severely impaired respiratory function and quality of life. Tumor resection was performed with sole lung volume reduction (LVR) in 5 patients, separate wedge resection in 3 patients, segmentectomy in 2 patients, and lobectomy in 6 patients. A bilateral LVR was performed in 5 patients. Quality of life was assessed at baseline and every 6 months postoperatively by the Short-form 36 (SF-36) item questionnaire. Results. Mean follow-up was 44 +/- 21 months. All tumors were pathologic stage I. There was no hospital mortality nor major morbidity. Significant improvements occurred for up to 36 months in the general health (p = 0.02) domain and for up to 24 months in physical functioning (p = 0.02), role physical (p = 0.005), and general health (P = 0.01) SF-36 domains. Associated improvements regarded dyspnea index (-1.3 +/- 0.6) forced expiratory volume in one second (+0.28 +/- 0.2L), residual volume (-1.18 +/- 0.5L) and 6-minute-walking test distance (+86 +/- 67 m). Actuarial 5-year survival was similar to that of patients with no cancer undergoing LVRS during the same period (68% vs 82%, p = not significant). Conclusions. Our study suggests that selected patients with stage I NSCLC and severe emphysema may significantly benefit from tailored combined surgery in terms of long-term quality of life and survival. (Ann Thorac Surg 2003;76:1821-7)

Pompeo, E., De Dominicis, E., Ambrogi, V., Mineo, D., Elia, S., Mineo, T.c. (2003). Quality of life after tailored combined surgery for stage I non-small-cell lung cancer and severe emphysema. ANNALS OF THORACIC SURGERY, 76(6), 1821-1827 [10.1016/S0003-4975(03)01302-X].

Quality of life after tailored combined surgery for stage I non-small-cell lung cancer and severe emphysema

POMPEO, EUGENIO;AMBROGI, VINCENZO;MINEO, DAVIDE;ELIA, STEFANO;MINEO, TOMMASO CLAUDIO
2003-01-01

Abstract

Background. We analyzed the early and long-term quality of life changes occurring in 16 patients undergoing tailored combined surgery for stage I non-small-cell lung cancer (NSCLC) and severe emphysema. Methods. Mean age was 65 +/- 5 years. All patients had severe emphysema with severely impaired respiratory function and quality of life. Tumor resection was performed with sole lung volume reduction (LVR) in 5 patients, separate wedge resection in 3 patients, segmentectomy in 2 patients, and lobectomy in 6 patients. A bilateral LVR was performed in 5 patients. Quality of life was assessed at baseline and every 6 months postoperatively by the Short-form 36 (SF-36) item questionnaire. Results. Mean follow-up was 44 +/- 21 months. All tumors were pathologic stage I. There was no hospital mortality nor major morbidity. Significant improvements occurred for up to 36 months in the general health (p = 0.02) domain and for up to 24 months in physical functioning (p = 0.02), role physical (p = 0.005), and general health (P = 0.01) SF-36 domains. Associated improvements regarded dyspnea index (-1.3 +/- 0.6) forced expiratory volume in one second (+0.28 +/- 0.2L), residual volume (-1.18 +/- 0.5L) and 6-minute-walking test distance (+86 +/- 67 m). Actuarial 5-year survival was similar to that of patients with no cancer undergoing LVRS during the same period (68% vs 82%, p = not significant). Conclusions. Our study suggests that selected patients with stage I NSCLC and severe emphysema may significantly benefit from tailored combined surgery in terms of long-term quality of life and survival. (Ann Thorac Surg 2003;76:1821-7)
2003
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/21 - CHIRURGIA TORACICA
English
Con Impact Factor ISI
volume reduction surgery; obstructive pulmonary-disease; assisted thoracic-surgery; bronchogenic-carcinoma; resection; thoracotomy; survival; pneumoplasty; lobectomy; exercise
Pompeo, E., De Dominicis, E., Ambrogi, V., Mineo, D., Elia, S., Mineo, T.c. (2003). Quality of life after tailored combined surgery for stage I non-small-cell lung cancer and severe emphysema. ANNALS OF THORACIC SURGERY, 76(6), 1821-1827 [10.1016/S0003-4975(03)01302-X].
Pompeo, E; De Dominicis, E; Ambrogi, V; Mineo, D; Elia, S; Mineo, Tc
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/49512
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