Background. We undertook to analyze the results of video-assisted thoracoscopic thymectomy through a left-sided approach in patients with autoimmune myasthenia. Methods. Between 1993 and 1997, 31 patients underwent thoracoscopic thymectomy by a uniform left-sided approach. There were 8 men and 23 women with a mean age of 34 +/- 12 years. Results. Preoperative duration of disease was 14.8 +/- 11 months. There were no operative deaths or major complications. The mean hospital stay was 5.2 +/- 2.8 days. Mean follow-up was 39.6 +/- 15 months and was 100% complete. At 48 months, remission and improvement rates were 36% and 96%, respectively. Shorter duration of symptoms (< 12 months) correlated with improved outcome (13 of 13 patients versus 10 of 14 patients; p = 0.036). Age, sex, Osserman class, corticosteroid therapy, presence of ectopic thymic tissue, and temporary postoperative symptom increase (deterioration) did not affect outcome. Conclusions. Thoracoscopic thymectomy facilitated the goal of early thymectomy. Through a left-sided approach, improvement or remission was achieved in more than 95% of the patients. Thoracoscopic thymectomy should be considered a valid less invasive alternative to the most radical open approaches

Mineo, T.c., Pompeo, E., Lerut, T.e., Bernardi, G., Coosemans, W., Nofroni, I. (2000). Thoracoscopic thymectomy in autoimmune myasthenia: Results of left-sided approach. ANNALS OF THORACIC SURGERY, 69(5), 1537-1541 [10.1016/S0003-4975(00)01237-6].

Thoracoscopic thymectomy in autoimmune myasthenia: Results of left-sided approach

MINEO, TOMMASO CLAUDIO;POMPEO, EUGENIO;BERNARDI, GIORGIO;
2000-01-01

Abstract

Background. We undertook to analyze the results of video-assisted thoracoscopic thymectomy through a left-sided approach in patients with autoimmune myasthenia. Methods. Between 1993 and 1997, 31 patients underwent thoracoscopic thymectomy by a uniform left-sided approach. There were 8 men and 23 women with a mean age of 34 +/- 12 years. Results. Preoperative duration of disease was 14.8 +/- 11 months. There were no operative deaths or major complications. The mean hospital stay was 5.2 +/- 2.8 days. Mean follow-up was 39.6 +/- 15 months and was 100% complete. At 48 months, remission and improvement rates were 36% and 96%, respectively. Shorter duration of symptoms (< 12 months) correlated with improved outcome (13 of 13 patients versus 10 of 14 patients; p = 0.036). Age, sex, Osserman class, corticosteroid therapy, presence of ectopic thymic tissue, and temporary postoperative symptom increase (deterioration) did not affect outcome. Conclusions. Thoracoscopic thymectomy facilitated the goal of early thymectomy. Through a left-sided approach, improvement or remission was achieved in more than 95% of the patients. Thoracoscopic thymectomy should be considered a valid less invasive alternative to the most radical open approaches
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/21 - Chirurgia Toracica
English
Con Impact Factor ISI
adult; aged; article; autoimmunity; clinical article; disease duration; ectopic tissue; electromyography; female; human; male; myasthenia gravis; outcomes research; postsynaptic inhibition; priority journal; remission; surgical approach; thoracoscopy; thymectomy; Adult; Endoscopy; Female; Follow-Up Studies; Humans; Length of Stay; Male; Myasthenia Gravis; Thoracic Surgery, Video-Assisted; Thoracoscopy; Thymectomy; Treatment Outcome
Mineo, T.c., Pompeo, E., Lerut, T.e., Bernardi, G., Coosemans, W., Nofroni, I. (2000). Thoracoscopic thymectomy in autoimmune myasthenia: Results of left-sided approach. ANNALS OF THORACIC SURGERY, 69(5), 1537-1541 [10.1016/S0003-4975(00)01237-6].
Mineo, Tc; Pompeo, E; Lerut, Te; Bernardi, G; Coosemans, W; Nofroni, I
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/49510
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