The effects of lamivudine (3TC) on in vitro infection of peripheral blood mononuclear cells (PBMC) from healthy donors with human T-cell lymphotropic virus type 1 (HTLV-1) were investigated. Direct measures of viral replication (viral DNA, RNA, and protein) all gave similar, very high 50% inhibitory concentrations in comparison with those previously reported for zidovudine. Nevertheless, 3TC inhibited HTLV-1-driven longterm growth of infected PBMC in vitro at concentrations (6.25 muM) which had poor or no direct antiviral effects, suggesting that another mechanism may be playing a role.

Balestrieri, E., Forte, G., Matteucci, C., Mastino, A., & Macchi, B. (2002). Effect of lamivudine on transmission of human T-cell lymphotropic virus type 1 to adult peripheral blood mononuclear cells in vitro. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 46(9), 3080-3083 [10.1128/AAC.46.9.3080-3083.2002].

Effect of lamivudine on transmission of human T-cell lymphotropic virus type 1 to adult peripheral blood mononuclear cells in vitro

Balestrieri, E;MATTEUCCI, CLAUDIA;MACCHI, BEATRICE
2002

Abstract

The effects of lamivudine (3TC) on in vitro infection of peripheral blood mononuclear cells (PBMC) from healthy donors with human T-cell lymphotropic virus type 1 (HTLV-1) were investigated. Direct measures of viral replication (viral DNA, RNA, and protein) all gave similar, very high 50% inhibitory concentrations in comparison with those previously reported for zidovudine. Nevertheless, 3TC inhibited HTLV-1-driven longterm growth of infected PBMC in vitro at concentrations (6.25 muM) which had poor or no direct antiviral effects, suggesting that another mechanism may be playing a role.
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Rilevanza internazionale
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Esperti anonimi
Settore MED/07 - Microbiologia e Microbiologia Clinica
Settore BIO/14
English
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Balestrieri, E., Forte, G., Matteucci, C., Mastino, A., & Macchi, B. (2002). Effect of lamivudine on transmission of human T-cell lymphotropic virus type 1 to adult peripheral blood mononuclear cells in vitro. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 46(9), 3080-3083 [10.1128/AAC.46.9.3080-3083.2002].
Balestrieri, E; Forte, G; Matteucci, C; Mastino, A; Macchi, B
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/49487
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