Background: To estimate the prevalence of infection with human herpes virus type 8 (HHV8) and the incidence of Kaposi's sarcoma among HHV8-infected individuals, we conducted a population-based, cross-sectional study in Latina. This area of central ItaLy was formerly endemic for malaria and it is now covered by a population-based cancer registry. Materials and Methods: Residual sera samples from 200 persons (100 men and 100 women) aged 50 years or older, randomly selected from a larger population-based survey on cardiovascular diseases, were tested for antibodies against HHV8. HHV8 seroprevalence and yearly incidence rates of Kaposi's sarcoma (KS) among HHV8-positive persons were computed. Results: HHV8 infection was not significantly higher in men (9.0%, 95% CI: 3.4-14.6) than in women (6.0%, 95% CI: 1.3-10.7). The estimated yearly incidence rate of KS among HHV8-positive persons was twice as high in men (1:2,200) as in women (1:4,110). Conclusion: These results were comparable to those derived from geographic areas at Low risk for KS where malaria was not endemic (e.g. Malta). The seemingly higher incidence of KS among HHV8-positive men suggests that different cofactors for the two sexes are LikeLy to play a role in KS etiology.

Serraino D., C.R. (2003). Infection with human herpesvirus type 8 and Kaposi's sarcoma in a central Italian area formerly endemic for malaria. INFECTION, 31(1), 47-50 [10.1007/s15010-002-3107-9].

Infection with human herpesvirus type 8 and Kaposi's sarcoma in a central Italian area formerly endemic for malaria

SARMATI, LOREDANA;ANDREONI, MASSIMO;
2003

Abstract

Background: To estimate the prevalence of infection with human herpes virus type 8 (HHV8) and the incidence of Kaposi's sarcoma among HHV8-infected individuals, we conducted a population-based, cross-sectional study in Latina. This area of central ItaLy was formerly endemic for malaria and it is now covered by a population-based cancer registry. Materials and Methods: Residual sera samples from 200 persons (100 men and 100 women) aged 50 years or older, randomly selected from a larger population-based survey on cardiovascular diseases, were tested for antibodies against HHV8. HHV8 seroprevalence and yearly incidence rates of Kaposi's sarcoma (KS) among HHV8-positive persons were computed. Results: HHV8 infection was not significantly higher in men (9.0%, 95% CI: 3.4-14.6) than in women (6.0%, 95% CI: 1.3-10.7). The estimated yearly incidence rate of KS among HHV8-positive persons was twice as high in men (1:2,200) as in women (1:4,110). Conclusion: These results were comparable to those derived from geographic areas at Low risk for KS where malaria was not endemic (e.g. Malta). The seemingly higher incidence of KS among HHV8-positive men suggests that different cofactors for the two sexes are LikeLy to play a role in KS etiology.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/17 - Malattie Infettive
English
Con Impact Factor ISI
virus antibody; adult; aged; article; cardiovascular disease; endemic disease; female; Herpes virus infection; high risk population; human; Human herpesvirus 8; Italy; Kaposi sarcoma; major clinical study; malaria; male; Malta; prevalence; risk factor; seroprevalence; Aged; Cross-Sectional Studies; Female; Herpesviridae Infections; Herpesvirus 8, Human; Humans; Incidence; Italy; Malaria; Male; Middle Aged; Sarcoma, Kaposi
Serraino D., C.R. (2003). Infection with human herpesvirus type 8 and Kaposi's sarcoma in a central Italian area formerly endemic for malaria. INFECTION, 31(1), 47-50 [10.1007/s15010-002-3107-9].
Serraino, D; Corona, Rm; Giuliani, M; Farchi, F; Sarmati, L; Uccella, I; Andreoni, M; Rezza, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/49468
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