Background: To estimate the prevalence of infection with human herpes virus type 8 (HHV8) and the incidence of Kaposi's sarcoma among HHV8-infected individuals, we conducted a population-based, cross-sectional study in Latina. This area of central ItaLy was formerly endemic for malaria and it is now covered by a population-based cancer registry. Materials and Methods: Residual sera samples from 200 persons (100 men and 100 women) aged 50 years or older, randomly selected from a larger population-based survey on cardiovascular diseases, were tested for antibodies against HHV8. HHV8 seroprevalence and yearly incidence rates of Kaposi's sarcoma (KS) among HHV8-positive persons were computed. Results: HHV8 infection was not significantly higher in men (9.0%, 95% CI: 3.4-14.6) than in women (6.0%, 95% CI: 1.3-10.7). The estimated yearly incidence rate of KS among HHV8-positive persons was twice as high in men (1:2,200) as in women (1:4,110). Conclusion: These results were comparable to those derived from geographic areas at Low risk for KS where malaria was not endemic (e.g. Malta). The seemingly higher incidence of KS among HHV8-positive men suggests that different cofactors for the two sexes are LikeLy to play a role in KS etiology.
Serraino D., C.R. (2003). Infection with human herpesvirus type 8 and Kaposi's sarcoma in a central Italian area formerly endemic for malaria. INFECTION, 31(1), 47-50.
|Tipologia:||Articolo su rivista|
|Citazione:||Serraino D., C.R. (2003). Infection with human herpesvirus type 8 and Kaposi's sarcoma in a central Italian area formerly endemic for malaria. INFECTION, 31(1), 47-50.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s15010-002-3107-9|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2003|
|Titolo:||Infection with human herpesvirus type 8 and Kaposi's sarcoma in a central Italian area formerly endemic for malaria|
|Autori:||Serraino D., Corona R.M., Giuliani M., Farchi F., Sarmati L., Uccella I., Andreoni M., Rezza G.|
|Appare nelle tipologie:||01 - Articolo su rivista|