Ceramides play an important role mediating different cell responses such as proliferation, differentiation, growth arrest and apoptosis. They are released upon sphingomyelin hydrolysis which occurs after triggering of a number of cell surface receptors including CD95. Ceramide generation also regulates glycosphingolipid and ganglioside metabolism. In particular, ganglioside GD3 biosynthesis represents an important event for the progression of apoptotic signals generated by CD95 and mediated by ceramide in hematopoietic cells. Copyright (C) 1999 Federation of European Biochemical Societies.
Malisan, F., Testi, R. (1999). Lipid signaling in CD95-mediated apoptosis. FEBS LETTERS, 452(2009/02/01 00:00:00.000), 100-103 [10.1016/S0014-5793(99)00543-8].
Lipid signaling in CD95-mediated apoptosis
MALISAN, FLORENCE;TESTI, ROBERTO
1999-01-01
Abstract
Ceramides play an important role mediating different cell responses such as proliferation, differentiation, growth arrest and apoptosis. They are released upon sphingomyelin hydrolysis which occurs after triggering of a number of cell surface receptors including CD95. Ceramide generation also regulates glycosphingolipid and ganglioside metabolism. In particular, ganglioside GD3 biosynthesis represents an important event for the progression of apoptotic signals generated by CD95 and mediated by ceramide in hematopoietic cells. Copyright (C) 1999 Federation of European Biochemical Societies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
