Gangliosides participate in development and tissue differentiation, Cross-linking of the apoptosis-inducing CD95 protein (also called Fas or APO-1) in lymphoid and myeloid tumor cells triggered GD3 ganglioside synthesis and transient accumulation. CD95-induced GD3 accumulation depended on integral receptor ''death domains'' and on activation of a family of cysteine proteases called caspases. Cell-permeating ceramides, which are potent inducers of apoptosis, also triggered GD3 synthesis, GD3 disrupted mitochondrial transmembrane potential (Delta psi(m),), and induced apoptosis, in a caspase-independent fashion. Transient overexpression of the GD3 synthase gene directly triggered apoptosis, Pharmacological inhibition of GD3 synthesis and exposure to GD3 synthase antisense oligodeoxynucleotides prevented CD95-induced apoptosis. Thus, GD3 ganglioside mediates the propagation of CD95-generated apoptotic signals in hematopoietic cells.
De Maria R., L.L. (1997). Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis. SCIENCE, 277(5332), 1652-1655.
Tipologia: | Articolo su rivista |
Citazione: | De Maria R., L.L. (1997). Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis. SCIENCE, 277(5332), 1652-1655. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1126/science.277.5332.1652 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 1997 |
Titolo: | Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis |
Autori: | |
Autori: | De Maria R., Lenti L., Malisan F., D'Agostino F., Tomassini B., Zeuner A., Rippo M.R., Testi R. |
Appare nelle tipologie: | 01 - Articolo su rivista |