The ozonation of 4-thiopyrimidine and 6-thiopurine nucleosides in presence of amines afforded selectively and under mild experimental conditions several cytidine and adenosine nucleosides. The same reaction carried out in presence of alcohols afforded O-4- or O-6-alkylated derivatives of the nucleosides.
Saladino, R., Crestini, C., Occhionero, F., Nicoletti, R. (1995). Ozonation of Thionucleosides. A New Chemical Transformation of 4-Thiouracil and 6-Thioguanine Nucleosides to Cytosine and Adenosine Counterparts. TETRAHEDRON, 51(12), 3607-3616 [10.1016/0040-4020(95)00076-K].
Ozonation of Thionucleosides. A New Chemical Transformation of 4-Thiouracil and 6-Thioguanine Nucleosides to Cytosine and Adenosine Counterparts.
CRESTINI, CLAUDIA;
1995-01-01
Abstract
The ozonation of 4-thiopyrimidine and 6-thiopurine nucleosides in presence of amines afforded selectively and under mild experimental conditions several cytidine and adenosine nucleosides. The same reaction carried out in presence of alcohols afforded O-4- or O-6-alkylated derivatives of the nucleosides.File in questo prodotto:
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