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EnglishThe work carried out in the authors' laboratories on the structure and expression of ribosomal protein genes in Xenopus is reviewed, with some comparisons with other systems. These genes form a class that shares several structural features, especially in the region surrounding the 5′ ends. These similar structures appear to be involved in coregulated expression that is attained at various regulatory levels: transcriptional, transcript processing and stability, and translational. Particular attention is paid here to the one operating at the translational level, which has been studied during Xenopus oogenesis and embryogenesis, and also during nutritional changes of Xenopus cultured cells. This regulation, which responds to the cellular need for new ribosomes, operates by changing the fraction of rp-mRNA engaged on polysomes, leaving each translated rp-mRNA molecule always fully loaded with ribosomes. Responsible for this translational behaviour is the typical 5′UTR, which characterizes all rp-mRNAs analyzed up to now, and that can bind in vitro some proteins, putative trans-acting factors for this translational regulation. © 1994 Kluwer Academic Publishers.
| Tipologia: | Articolo su rivista |
| Citazione: | Pierandrei-Amaldi, P., & Amaldi, F. (1994). Aspects of regulation of ribosomal protein synthesis in Xenopus laevis - Review. GENETICA, 94, 181-193. |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore BIO/11 |
| Revisione (peer review): | Sì, ma tipo non specificato |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/BF01443432 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 1994 |
| Titolo: | Aspects of regulation of ribosomal protein synthesis in Xenopus laevis - Review |
| Autori: | |
| Autori: | Pierandrei-Amaldi, P; Amaldi, F |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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