Initiation, progression and evasion are sequential steps in cancer formation, with autonomous cell proliferation as a final outcome. Genetic or epigenetic alterations of key regulatory genes of the cell cycle are frequently associated with these phenomena. Recently, chromosomal instability, a long-supposed driving force of tumorigenesis, was associated with dysregulation of mitotic genes, providing advantages to tumor cells. Numerous molecules thus provide a key link in the chain of relationships between chromosomal instability and cancer. Here, we discuss emerging evidence revealing that two p53 family members, p53 and p73, might be key regulatory genes at the heart of the relationship between chromosomal instability and cancer. We argue that the role of members of the p53 family as tumor suppressor proteins, their impact on the control of cellular ploidy, and their newly emerging connection with mitotic checkpoint regulatory genes support the suggestion that p73 and p53 could be two of the missing links among chromosomal instability, the mitotic checkpoint and cancer.

Tomasini R., M.T. (2008). The impact of p53 and p73 on aneuploidy and cancer. TRENDS IN CELL BIOLOGY, 18(5), 244-252 [10.1016/j.tcb.2008.03.003].

The impact of p53 and p73 on aneuploidy and cancer

MELINO, GENNARO
2008

Abstract

Initiation, progression and evasion are sequential steps in cancer formation, with autonomous cell proliferation as a final outcome. Genetic or epigenetic alterations of key regulatory genes of the cell cycle are frequently associated with these phenomena. Recently, chromosomal instability, a long-supposed driving force of tumorigenesis, was associated with dysregulation of mitotic genes, providing advantages to tumor cells. Numerous molecules thus provide a key link in the chain of relationships between chromosomal instability and cancer. Here, we discuss emerging evidence revealing that two p53 family members, p53 and p73, might be key regulatory genes at the heart of the relationship between chromosomal instability and cancer. We argue that the role of members of the p53 family as tumor suppressor proteins, their impact on the control of cellular ploidy, and their newly emerging connection with mitotic checkpoint regulatory genes support the suggestion that p73 and p53 could be two of the missing links among chromosomal instability, the mitotic checkpoint and cancer.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/11
English
Con Impact Factor ISI
protein p53; protein p73; tumor suppressor protein; aneuploidy; carcinogenesis; chromosomal instability; chromosome; mitosis; nonhuman; phenotype; priority journal; protein family; regulator gene; review; tumor cell; tumor gene; Aneuploidy; Animals; Cell Transformation, Neoplastic; Chromosomes; Disease Progression; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Genes, Dominant; Humans; Mice; Mitosis; Neoplasms; Nuclear Proteins; Phenotype; Ploidies; Tumor Suppressor Protein p53; Tumor Suppressor Proteins
Tomasini R., M.T. (2008). The impact of p53 and p73 on aneuploidy and cancer. TRENDS IN CELL BIOLOGY, 18(5), 244-252 [10.1016/j.tcb.2008.03.003].
Tomasini, R; Mak, Tw; Melino, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/47810
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