The protease inhibitor atazanavir (ATV) can be used either boosted by ritonavir (ATV300/r) or unboosted (ATV400). To date, however, genotypic resistance scores (GRSs) have been developed only for boosted-ATV. We have determined GRS associated with virologic response (VR) for both ATV300/r and ATV400 in highly pre-treated HIV-1 infected patients.

Santoro, M., Bertoli, A., Lorenzini, P., CECCHERINI SILBERSTEIN, F., Gianotti, N., Mussini, C., et al. (2009). Two different patterns of mutations are involved in the genotypic resistance score for atazanavir boosted versus unboosted by ritonavir in multiple failing patients. INFECTION, 37(3), 233-243 [10.1007/s15010-008-8065-4].

Two different patterns of mutations are involved in the genotypic resistance score for atazanavir boosted versus unboosted by ritonavir in multiple failing patients

SANTORO, MARIA;BERTOLI, ADA;CECCHERINI SILBERSTEIN, FRANCESCA;PERNO, CARLO FEDERICO
2009-06-01

Abstract

The protease inhibitor atazanavir (ATV) can be used either boosted by ritonavir (ATV300/r) or unboosted (ATV400). To date, however, genotypic resistance scores (GRSs) have been developed only for boosted-ATV. We have determined GRS associated with virologic response (VR) for both ATV300/r and ATV400 in highly pre-treated HIV-1 infected patients.
giu-2009
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA
English
Con Impact Factor ISI
Codon; Chi-Square Distribution; Humans; CD4 Lymphocyte Count; HIV-1; Multivariate Analysis; Antiretroviral Therapy, Highly Active; Treatment Outcome; Drug Synergism; Oligopeptides; Male; HIV Protease Inhibitors; Amino Acid Sequence; Pyridines; Longitudinal Studies; RNA, Viral; Viral Load; Genotype; Drug Resistance, Viral; Prospective Studies; HIV Infections; Logistic Models; Ritonavir; Drug Resistance, Multiple, Viral; Viremia; Mutation; Female
Santoro, M., Bertoli, A., Lorenzini, P., CECCHERINI SILBERSTEIN, F., Gianotti, N., Mussini, C., et al. (2009). Two different patterns of mutations are involved in the genotypic resistance score for atazanavir boosted versus unboosted by ritonavir in multiple failing patients. INFECTION, 37(3), 233-243 [10.1007/s15010-008-8065-4].
Santoro, M; Bertoli, A; Lorenzini, P; CECCHERINI SILBERSTEIN, F; Gianotti, N; Mussini, C; Torti, C; Di Perri, G; Barbarini, G; Bini, T; Melzi, S; Cara...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/47515
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