Adipokines may significantly influence the growth and proliferation of tumor stroma and malignant cells within. Reduced adiponectin and increased leptin serum levels were found in colorectal cancer (CRC) patients. Recently, it has been demonstrated that tumor necrosis factor-alpha (TNF-alpha) is able to induce dose-dependent changes in serum adipokine levels. Thus, aims of this study were to evaluate the possible associations between adipokines, TNF-alpha and clinicopathological variables of CRC patients and to analyze their possible prognostic value in predicting relapse-free and overall survival.
Guadagni, F., Roselli, M., Martini, F., Spila, A., Riondino, S., D'Alessandro, R., et al. (2009). Prognostic significance of serum adipokine levels in colorectal cancer patients. ANTICANCER RESEARCH, 29(8), 3321-3327.
Prognostic significance of serum adipokine levels in colorectal cancer patients
ROSELLI, MARIO;Riondino, S;Formica, V;
2009-08-01
Abstract
Adipokines may significantly influence the growth and proliferation of tumor stroma and malignant cells within. Reduced adiponectin and increased leptin serum levels were found in colorectal cancer (CRC) patients. Recently, it has been demonstrated that tumor necrosis factor-alpha (TNF-alpha) is able to induce dose-dependent changes in serum adipokine levels. Thus, aims of this study were to evaluate the possible associations between adipokines, TNF-alpha and clinicopathological variables of CRC patients and to analyze their possible prognostic value in predicting relapse-free and overall survival.| File | Dimensione | Formato | |
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Prognostic Significance of Serum Adipokine Levels in Colorectal Cancer Patients.pdf
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