A novel one-pot TiO2-catalyzed synthesis of nucleobases and acyclonucleosides from formamide is reported. Since formamide can be formed under prebiotic conditions, these reactions have implications for the origin of life. While a number of purine derivatives have been found as products of non-TiO2-catalyzed reactions, important compounds that would not otherwise occur (namely, thymine, 5-hydroxymethyluracil, and acyclonucleosides) are formed in acceptable yields by TiO2-catalyzed reactions. Moreover, TiO2 selectively affects the rates of degradation of nucleobases, as single units and when embedded in polynucleotides.
Saladino, R., Ciambecchini, U., Crestini, C., Costanzo, G., Negri, R., Di Mauro, E. (2003). One-pot TiO2-catalyzed synthesis of nucleic bases and acyclonucleosides from formamide: Implications for the origin of life. CHEMBIOCHEM, 6(4), 514 [10.1002/cbic.200300567].
One-pot TiO2-catalyzed synthesis of nucleic bases and acyclonucleosides from formamide: Implications for the origin of life
CRESTINI, CLAUDIA;
2003-01-01
Abstract
A novel one-pot TiO2-catalyzed synthesis of nucleobases and acyclonucleosides from formamide is reported. Since formamide can be formed under prebiotic conditions, these reactions have implications for the origin of life. While a number of purine derivatives have been found as products of non-TiO2-catalyzed reactions, important compounds that would not otherwise occur (namely, thymine, 5-hydroxymethyluracil, and acyclonucleosides) are formed in acceptable yields by TiO2-catalyzed reactions. Moreover, TiO2 selectively affects the rates of degradation of nucleobases, as single units and when embedded in polynucleotides.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
