Spontaneous intracerebral hemorrhage (SICH) is a subtype of stroke associated with high mortality and devastating disabilities. Therefore, identifying non-invasive biomarkers for SICH would have a tremendous clinical impact. MicroRNAs (miRNAs) are non-coding single-stranded RNAs containing 21-23 nucleotides that control the activity of various protein-coding genes through post-transcriptional repression. In this systematic review, we report the recent clinical evidence on the role of miRNAs as biomarkers for the prediction, prognosis, early detection, and risk stratification of SICH.
Sultan, W., Machado, L., Ali, M.g., Tramontana, A., Bayoumy, A.e., Baxter, S.g., et al. (2022). MicroRNAs as biomarkers in spontaneous intracerebral hemorrhage: a systematic review of recent clinical evidence. CLINICAL NEUROLOGY AND NEUROSURGERY, 213, 1-10 [10.1016/j.clineuro.2022.107130].
MicroRNAs as biomarkers in spontaneous intracerebral hemorrhage: a systematic review of recent clinical evidence
Bilotta,F
2022-01-01
Abstract
Spontaneous intracerebral hemorrhage (SICH) is a subtype of stroke associated with high mortality and devastating disabilities. Therefore, identifying non-invasive biomarkers for SICH would have a tremendous clinical impact. MicroRNAs (miRNAs) are non-coding single-stranded RNAs containing 21-23 nucleotides that control the activity of various protein-coding genes through post-transcriptional repression. In this systematic review, we report the recent clinical evidence on the role of miRNAs as biomarkers for the prediction, prognosis, early detection, and risk stratification of SICH.| File | Dimensione | Formato | |
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