Nontumoral notochordal inclusions in vertebral bone marrow give rise to MRI-detectable lesion without osteolysis, and their detection may cause concern or overtreatment. These lesions likely arise from dislocation of notochordal cells from the nucleus pulposus early in life, followed by growth in a permissive bone marrow microenvironment. We present a case of nontumoral notochordal inclusions in vertebral bone marrow, giving rise to an MRI detectable lesion without osteolysis. MRI detection of such lesions may cause concern or overtreatment. Quite distinct from chordomas, these lesions likely arise from dislocation of notochordal cells from the nucleus pulposus early in life, followed by growth in a permissive bone marrow microenvironment.

Corsi, A., DE MAIO, F., Mancini, F., Ippolito, E., Riminucci, M., Bianco, P. (2008). Notochordal inclusions in the vertebral bone marrow. JOURNAL OF BONE AND MINERAL RESEARCH, 23(4), 572-575 [10.1359/jbmr.071204].

Notochordal inclusions in the vertebral bone marrow

DE MAIO, FERNANDO;MANCINI, FEDERICO;IPPOLITO, ERNESTO;
2008-04-01

Abstract

Nontumoral notochordal inclusions in vertebral bone marrow give rise to MRI-detectable lesion without osteolysis, and their detection may cause concern or overtreatment. These lesions likely arise from dislocation of notochordal cells from the nucleus pulposus early in life, followed by growth in a permissive bone marrow microenvironment. We present a case of nontumoral notochordal inclusions in vertebral bone marrow, giving rise to an MRI detectable lesion without osteolysis. MRI detection of such lesions may cause concern or overtreatment. Quite distinct from chordomas, these lesions likely arise from dislocation of notochordal cells from the nucleus pulposus early in life, followed by growth in a permissive bone marrow microenvironment.
apr-2008
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/33 - MALATTIE APPARATO LOCOMOTORE
English
Con Impact Factor ISI
Magnetic Resonance Imaging; Bone Marrow; Humans; Adult; Low Back Pain; Notochord; Male
Corsi, A., DE MAIO, F., Mancini, F., Ippolito, E., Riminucci, M., Bianco, P. (2008). Notochordal inclusions in the vertebral bone marrow. JOURNAL OF BONE AND MINERAL RESEARCH, 23(4), 572-575 [10.1359/jbmr.071204].
Corsi, A; DE MAIO, F; Mancini, F; Ippolito, E; Riminucci, M; Bianco, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/45802
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