Tildrakizumab 200 mg: a step forward in psoriasis treatment with added metabolic benefits

Background: Psoriasis is frequently associated with metabolic syndrome and an increased cardiovascularrisk. Tildrakizumab, an IL-23 inhibitor, may affect metabolic parameters in addition to improving skinseverity.Aim of the study: To evaluate the impact of increasing tildrakizumab dosage on lipid and glucoselevels in psoriasis patients with metabolic syndrome who showed a partial response to the standard100 mg dose.Materials and methods: Twenty-five patients with psoriasis and metabolic syndrome were enrolled ina 52-week prospective study. After 16 weeks of treatment with 100 mg tildrakizumab, patients with anabsolute PASI >2 were switched to 200 mg. Total cholesterol, LDL, and glucose were measured atbaseline, week 16, week 40, alongside PASI and DLQI.Results: At baseline, mean total cholesterol, LDL, and glucose were 190.7, 120.1, and 99.4 mg/dL,respectively. The 100 mg dose did not result in significant metabolic changes at week 16. However,switching to 200 mg tildrakizumab led to significant reductions at week 40 in total cholesterol (178.3 mg/dL), LDL (110.1 mg/dL), and glucose (87.2 mg/dL) (all p < 0.05). Significant improvements in PASI (1.2)and DLQI (0.2) were also observed (p < 0.05).Conclusions: Increasing the tildrakizumab dose to 200 mg in partial responders with metabolicsyndrome significantly improved both skin severity and metabolic profiles, lowering cholesterol, LDL,and glucose. These findings suggest a possible dose-dependent effect of tildrakizumab on metabolicparameters through enhanced IL-23 inhibition