Caspases are proteases that regulate apoptosis as well as inflammation. Denecker et al. show that caspase-14 controls the maturation of the epidermis by proteolytically processing filaggrin. The ultimate products of this cleavage prevent UVB photodamage and water loss, affecting skin osmolarity and moisture. Although this work sets caspase-14 apart from its family members, it also reinforces their role in host defence responses.
Nicotera, P., Melino, G. (2007). Caspase-14 and epidermis maturation. NATURE CELL BIOLOGY, 9(6), 621-622 [10.1038/ncb0607-621].
Caspase-14 and epidermis maturation
MELINO, GENNARO
2007-01-01
Abstract
Caspases are proteases that regulate apoptosis as well as inflammation. Denecker et al. show that caspase-14 controls the maturation of the epidermis by proteolytically processing filaggrin. The ultimate products of this cleavage prevent UVB photodamage and water loss, affecting skin osmolarity and moisture. Although this work sets caspase-14 apart from its family members, it also reinforces their role in host defence responses.File in questo prodotto:
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