Caspases are proteases that regulate apoptosis as well as inflammation. Denecker et al. show that caspase-14 controls the maturation of the epidermis by proteolytically processing filaggrin. The ultimate products of this cleavage prevent UVB photodamage and water loss, affecting skin osmolarity and moisture. Although this work sets caspase-14 apart from its family members, it also reinforces their role in host defence responses.

Nicotera P., M.G. (2007). Caspase-14 and epidermis maturation. NATURE CELL BIOLOGY, 9(6), 621-622 [10.1038/ncb0607-621].

Caspase-14 and epidermis maturation

MELINO, GENNARO
2007

Abstract

Caspases are proteases that regulate apoptosis as well as inflammation. Denecker et al. show that caspase-14 controls the maturation of the epidermis by proteolytically processing filaggrin. The ultimate products of this cleavage prevent UVB photodamage and water loss, affecting skin osmolarity and moisture. Although this work sets caspase-14 apart from its family members, it also reinforces their role in host defence responses.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/11
Settore BIO/10
English
Con Impact Factor ISI
caspase 14; death receptor; filaggrin; interleukin 1beta converting enzyme; profilaggrin; protein bcl 2; proteinase; Casp14 protein, mouse; caspase; intermediate filament protein; amino acid sequence; apoptosis; article; cell maturation; enzyme activity; enzyme mechanism; enzyme specificity; enzyme substrate; epidermis cell; host resistance; human; hydration; inflammation; keratinization; keratinocyte; moisture; nonhuman; osmolarity; osmoregulation; priority journal; protein degradation; protein dephosphorylation; protein function; protein phosphorylation; protein processing; radiation injury; radiation protection; radiosensitivity; regulatory mechanism; skin; tandem repeat; ultraviolet B radiation; water loss; aging; animal; cell death; cell differentiation; dehydration; electrolyte balance; enzymology; epidermis; genetics; metabolism; mouse; note; pathophysiology; physiology; radiation exposure; ultraviolet radiation; Aging; Animals; Caspases; Cell Death; Cell Differentiation; Dehydration; Epidermis; Humans; Intermediate Filament Proteins; Keratinocytes; Mice; Osmolar Concentration; Ultraviolet Rays; Water-Electrolyte Balance
Nicotera P., M.G. (2007). Caspase-14 and epidermis maturation. NATURE CELL BIOLOGY, 9(6), 621-622 [10.1038/ncb0607-621].
Nicotera, P; Melino, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/45351
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