Four X-linked loci showing homology with a previously described Y- linked polymorphic locus (DYS413) were identified and characterized. By fluorescent in situ hybridization (FISH), somatic cell hybrids, and YAC screening, the X-linked members of this small family of sequences (CAIII) all map in Xp22, while the Y members map in Yq 11. These loci contribute to the overall similarity of the two genomic regions. All of the CAIII loci contain an internal microsatellite of the (CA)(n) type. The microsatellites display extensive length polymorphism in two of the X-linked members as well as in the Y members. In addition, common sequence variants are found in the portions flanking the microsatellites in two of the X-linked members. Our results indicate that, during the evolution of this family, length variation on the Y chromosome was accumulated at a rate not slower than that on the X chromosome. Finally, these sequences represent a model system with which to analyze human populations for similar X- and Y-linked polymorphisms.

Malaspina, P., Ciminelli, B.M., Viggiano, L., Iodice, C., Cruciani, F., Santolamazza, P., et al. (1997). Characterization of a small family (CAIII) of microsatellite-containing sequences with X-Y homology. JOURNAL OF MOLECULAR EVOLUTION, 44(6), 652-659 [10.1007/PL00006189].

Characterization of a small family (CAIII) of microsatellite-containing sequences with X-Y homology

MALASPINA, PATRIZIA;CIMINELLI, BIANCA MARIA;IODICE, CARLA;TERRENATO, LUCIANO;NOVELLETTO, ANDREA
1997

Abstract

Four X-linked loci showing homology with a previously described Y- linked polymorphic locus (DYS413) were identified and characterized. By fluorescent in situ hybridization (FISH), somatic cell hybrids, and YAC screening, the X-linked members of this small family of sequences (CAIII) all map in Xp22, while the Y members map in Yq 11. These loci contribute to the overall similarity of the two genomic regions. All of the CAIII loci contain an internal microsatellite of the (CA)(n) type. The microsatellites display extensive length polymorphism in two of the X-linked members as well as in the Y members. In addition, common sequence variants are found in the portions flanking the microsatellites in two of the X-linked members. Our results indicate that, during the evolution of this family, length variation on the Y chromosome was accumulated at a rate not slower than that on the X chromosome. Finally, these sequences represent a model system with which to analyze human populations for similar X- and Y-linked polymorphisms.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/18 - Genetica
English
Con Impact Factor ISI
human Y chromosome; Y polymorphisms; X-Y homology; microsatellites
Malaspina, P., Ciminelli, B.M., Viggiano, L., Iodice, C., Cruciani, F., Santolamazza, P., et al. (1997). Characterization of a small family (CAIII) of microsatellite-containing sequences with X-Y homology. JOURNAL OF MOLECULAR EVOLUTION, 44(6), 652-659 [10.1007/PL00006189].
Malaspina, P; Ciminelli, Bm; Viggiano, L; Iodice, C; Cruciani, F; Santolamazza, P; Sellitto, D; Scozzari, R; Terrenato, L; Rocchi, M; Novelletto, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/45005
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