In a study of 908 males from Europe, northern Africa, and western Asia, the variation of four Y-linked dinucleotide microsatellites was analyzed within three "frames" that are defined by mutations that are nonrecurrent, or nearly so. The rapid generation and extinction of new dinucleotide length variants causes the haplotypes within each lineage to diverge from one another. We constructed networks of "adjacent" haplotypes within each frame, by assuming changes of a single dinucleotide unit. Two small and six large networks were obtained, the latter including 94.9% of the sampled Y chromosomes. We show that the phenetic relationships among haplotypes, represented as a network, result largely from common descent and subsequent molecular radiation. The grouping of haplotypes of the same network thus fits an evolutionarily relevant criterion. Notably, this method allows the total diversity within a sample to be partitioned. Networks can be considered optimal markers for population studies, because reliable frequency estimates can be obtained in small samples. We present synthetic maps describing the incidence of different Y-chromosomal lineages in the extant human populations of the surveyed areas. Dinucleotide diversity also was used to infer time intervals for the coalescence of each network.

Malaspina, P., Cruciani, F., Ciminelli, B.m., Terrenato, L., Santolamazza, P., Alonso, A., et al. (1998). Network analyses of Y-chromosomal types in Europe, Northern Africa, and Western Asia reveal specific patterns of geographic distribution. AMERICAN JOURNAL OF HUMAN GENETICS, 63(3), 847-860 [10.1086/301999].

Network analyses of Y-chromosomal types in Europe, Northern Africa, and Western Asia reveal specific patterns of geographic distribution

MALASPINA, PATRIZIA;CIMINELLI, BIANCA MARIA;TERRENATO, LUCIANO;NOVELLETTO, ANDREA
1998-01-01

Abstract

In a study of 908 males from Europe, northern Africa, and western Asia, the variation of four Y-linked dinucleotide microsatellites was analyzed within three "frames" that are defined by mutations that are nonrecurrent, or nearly so. The rapid generation and extinction of new dinucleotide length variants causes the haplotypes within each lineage to diverge from one another. We constructed networks of "adjacent" haplotypes within each frame, by assuming changes of a single dinucleotide unit. Two small and six large networks were obtained, the latter including 94.9% of the sampled Y chromosomes. We show that the phenetic relationships among haplotypes, represented as a network, result largely from common descent and subsequent molecular radiation. The grouping of haplotypes of the same network thus fits an evolutionarily relevant criterion. Notably, this method allows the total diversity within a sample to be partitioned. Networks can be considered optimal markers for population studies, because reliable frequency estimates can be obtained in small samples. We present synthetic maps describing the incidence of different Y-chromosomal lineages in the extant human populations of the surveyed areas. Dinucleotide diversity also was used to infer time intervals for the coalescence of each network.
1998
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/18 - GENETICA
English
Con Impact Factor ISI
article; Asia; biodiversity; DNA polymorphism; Europe; gene mapping; genetic analysis; geographic distribution; haplotype; human; male; North Africa; phylogeny; priority journal; Y chromosome; Africa, Northern; Asia, Western; Dinucleotide Repeats; Europe; Evolution, Molecular; Geography; Haplotypes; Humans; Male; Models, Genetic; Models, Statistical; Variation (Genetics); Y Chromosome
Malaspina, P., Cruciani, F., Ciminelli, B.m., Terrenato, L., Santolamazza, P., Alonso, A., et al. (1998). Network analyses of Y-chromosomal types in Europe, Northern Africa, and Western Asia reveal specific patterns of geographic distribution. AMERICAN JOURNAL OF HUMAN GENETICS, 63(3), 847-860 [10.1086/301999].
Malaspina, P; Cruciani, F; Ciminelli, Bm; Terrenato, L; Santolamazza, P; Alonso, A; Banyko, J; Brdicka, R; Garcia, O; Gaudiano, C; Guanti, G; Kidd, K;...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/45001
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