Modified lipoproteins, particularly oxidized LDLs, are believed to evoke an inflammatory response which participates in all stages of atherosclerosis. Disposal of these particles is mediated through receptors which may trigger proinflammatory signaling pathways leading to vascular injury. This study was aimed at assessing the role in atherogenesis of one of these receptors, galectin-3.

Iacobini, C., Menini, S., Ricci, C., Scipioni, A., Sansoni, V., Cordone, S., et al. (2009). Accelerated lipid-induced atherogenesis in galectin-3-deficient mice: role of lipoxidation via receptor-mediated mechanisms. ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, 29(6), 831-836 [10.1161/ATVBAHA.109.186791].

Accelerated lipid-induced atherogenesis in galectin-3-deficient mice: role of lipoxidation via receptor-mediated mechanisms

FEDERICI, MASSIMO;
2009-06-01

Abstract

Modified lipoproteins, particularly oxidized LDLs, are believed to evoke an inflammatory response which participates in all stages of atherosclerosis. Disposal of these particles is mediated through receptors which may trigger proinflammatory signaling pathways leading to vascular injury. This study was aimed at assessing the role in atherogenesis of one of these receptors, galectin-3.
giu-2009
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore M-EDF/01 - METODI E DIDATTICHE DELLE ATTIVITA' MOTORIE
Settore MED/09 - MEDICINA INTERNA
English
Con Impact Factor ISI
Atherosclerosis; Macrophages; Animals; Apoptosis; Disease Progression; Disease Models, Animal; Lipid Peroxidation; Mice, Knockout; Lymphocyte Activation; Transcription Factors; Receptors, Immunologic; Receptors, Scavenger; Oxidative Stress; Inflammation Mediators; Monocytes; Time Factors; Th1 Cells; Signal Transduction; Aorta; Galectin 3; Mice; Chemotaxis, Leukocyte; Aortitis; Diet, Atherogenic; Aortic Diseases; Mice, Inbred C57BL; Lipoproteins, LDL; Female
Iacobini, C., Menini, S., Ricci, C., Scipioni, A., Sansoni, V., Cordone, S., et al. (2009). Accelerated lipid-induced atherogenesis in galectin-3-deficient mice: role of lipoxidation via receptor-mediated mechanisms. ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, 29(6), 831-836 [10.1161/ATVBAHA.109.186791].
Iacobini, C; Menini, S; Ricci, C; Scipioni, A; Sansoni, V; Cordone, S; Taurino, M; Serino, M; Marano, G; Federici, M; Pricci, F; Pugliese, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/44789
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