Tn this work we focus on a microsatellite-defined Y-chromosomal lineage (network 1.2) identified by us and reported in previous studies, whose geographic distribution and antiquity appear to be compatible with the Neolithic spread of farmers. Here, we set network 1.2 in the Y-chromosomal phylogenetic tree, date it with respect to other lineages associated with the same movements by other authors, examine its diversity by means of tri- and tetranucleotide loci and discuss the implications hi reconstructing the spread of this group of chromosomes in the Mediterranean area. Our results define a tripartite phylogeny wit-bin HG 9 (Rosser et al. 2000) with the deepest branching defined by alleles T (Haplogroup Eu 10) or G (Haplogroup Eu9) at M172 (Semino et al. 2000), and a subsequent branching within Eu9 defined by network 1.2. Population distributions of HG 9 and network 1.2 show that their occurrence in the surveyed area is not due to the spread of people from a single parental population but, rather, to a process punctuated by at least two phases. Our data identify the wide area of the Balkans, Aegean and Anatolia as the possible homeland harbouring the largest variation within network 1.2. The use of recently proposed tests based on the stepwise mutation model suggests that its spread was associated to a population expansion, xvith a high rate of male gene flow in the Turkish Greek area.

Malaspina, P., Tsopanomichalou, M., Duman, T., Stefan, M., Silvestri, A., Rinaldi, B., et al. (2001). A multistep process for the dispersal of a Y chromosomal lineage in the Mediterranean area. ANNALS OF HUMAN GENETICS, 65(4), 339-349 [10.1017/S0003480001008727].

A multistep process for the dispersal of a Y chromosomal lineage in the Mediterranean area

MALASPINA, PATRIZIA;TERRENATO, LUCIANO;NOVELLETTO, ANDREA
2001-01-01

Abstract

Tn this work we focus on a microsatellite-defined Y-chromosomal lineage (network 1.2) identified by us and reported in previous studies, whose geographic distribution and antiquity appear to be compatible with the Neolithic spread of farmers. Here, we set network 1.2 in the Y-chromosomal phylogenetic tree, date it with respect to other lineages associated with the same movements by other authors, examine its diversity by means of tri- and tetranucleotide loci and discuss the implications hi reconstructing the spread of this group of chromosomes in the Mediterranean area. Our results define a tripartite phylogeny wit-bin HG 9 (Rosser et al. 2000) with the deepest branching defined by alleles T (Haplogroup Eu 10) or G (Haplogroup Eu9) at M172 (Semino et al. 2000), and a subsequent branching within Eu9 defined by network 1.2. Population distributions of HG 9 and network 1.2 show that their occurrence in the surveyed area is not due to the spread of people from a single parental population but, rather, to a process punctuated by at least two phases. Our data identify the wide area of the Balkans, Aegean and Anatolia as the possible homeland harbouring the largest variation within network 1.2. The use of recently proposed tests based on the stepwise mutation model suggests that its spread was associated to a population expansion, xvith a high rate of male gene flow in the Turkish Greek area.
2001
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/18 - GENETICA
English
Con Impact Factor ISI
microsatellite DNA; trinucleotide; agricultural worker; allele; article; biodiversity; chromosome; controlled study; gene locus; gene mutation; gene transfer; genetic variability; geographic distribution; Greece; haplotype; human; male; parent; phylogeny; population; population growth; priority journal; Southern Europe; statistical model; Turkey (republic); Y chromosome; Alleles; Asia, Western; Egypt; Europe; Founder Effect; Gene Frequency; Humans; Male; Mediterranean Region; Microsatellite Repeats; Phylogeny; Variation (Genetics); Y Chromosome
Malaspina, P., Tsopanomichalou, M., Duman, T., Stefan, M., Silvestri, A., Rinaldi, B., et al. (2001). A multistep process for the dispersal of a Y chromosomal lineage in the Mediterranean area. ANNALS OF HUMAN GENETICS, 65(4), 339-349 [10.1017/S0003480001008727].
Malaspina, P; Tsopanomichalou, M; Duman, T; Stefan, M; Silvestri, A; Rinaldi, B; Garcia, O; Giparaki, M; Plata, E; Kozlov, A; Barbujani, G; Vernesi, C...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/44448
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