The global pattern of variation at the homologous microsatellite loci DYS413 (Yq11) and DXS8174 and DXS8175 (Xp22) was analyzed by examination of 30 world populations from four continents, accounting for more than 1,100 chromosomes per locus. The data showed discordant patterns of among-and within-population gene diversity for the Y-linked and the X-linked microsatellites. For the Y-linked polymorphism, all groups of populations displayed high F-ST values (the correlation between random haplotypes within subpopulations, relative to haplotypes of the total population) and showed a general trend for the haplotypes to cluster in a population-specific way. This was especially true for sub-Saharan African populations. The data also indicated that a large fraction of the variation among populations was due to the accumulation of new variants associated with the radiation process. Europeans exhibited the highest level of within-population haplotype diversity, whereas sub-Saharan Africans showed the lowest. In contrast, data for the two X-linked polymorphisms were concordant in showing lower F-ST values, as compared with those for DYS413, but higher within-population variances, for African versus non-African populations. Whereas the results for the X-linked loci agreed with a model of greater antiquity for the African populations, those for DYS413 showed a confounding pattern that is apparently at odds with such a model. Possible factors involved in this differential structuring for homologous X and Y microsatellite polymorphisms are discussed.

Scozzari, R., Cruciani, F., Malaspina, P., Santolamazza, P., Ciminelli, B.m., Torroni, A., et al. (1997). Differential structuring of human populations for homologous X and Y microsatellite loci. AMERICAN JOURNAL OF HUMAN GENETICS, 61(3), 719-733.

Differential structuring of human populations for homologous X and Y microsatellite loci

MALASPINA, PATRIZIA;CIMINELLI, BIANCA MARIA;TERRENATO, LUCIANO;NOVELLETTO, ANDREA
1997-01-01

Abstract

The global pattern of variation at the homologous microsatellite loci DYS413 (Yq11) and DXS8174 and DXS8175 (Xp22) was analyzed by examination of 30 world populations from four continents, accounting for more than 1,100 chromosomes per locus. The data showed discordant patterns of among-and within-population gene diversity for the Y-linked and the X-linked microsatellites. For the Y-linked polymorphism, all groups of populations displayed high F-ST values (the correlation between random haplotypes within subpopulations, relative to haplotypes of the total population) and showed a general trend for the haplotypes to cluster in a population-specific way. This was especially true for sub-Saharan African populations. The data also indicated that a large fraction of the variation among populations was due to the accumulation of new variants associated with the radiation process. Europeans exhibited the highest level of within-population haplotype diversity, whereas sub-Saharan Africans showed the lowest. In contrast, data for the two X-linked polymorphisms were concordant in showing lower F-ST values, as compared with those for DYS413, but higher within-population variances, for African versus non-African populations. Whereas the results for the X-linked loci agreed with a model of greater antiquity for the African populations, those for DYS413 showed a confounding pattern that is apparently at odds with such a model. Possible factors involved in this differential structuring for homologous X and Y microsatellite polymorphisms are discussed.
1997
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/18 - GENETICA
English
Con Impact Factor ISI
HUMAN MITOCHONDRIAL-DNA; RECENT AFRICAN ORIGIN; TANDEM REPEAT LOCI; HUMAN-EVOLUTION; SEQUENCE POLYMORPHISM; HIGH-RESOLUTION; MUTATION-RATE; GENETIC-MAP; CHROMOSOME; HAPLOTYPES
Scozzari, R., Cruciani, F., Malaspina, P., Santolamazza, P., Ciminelli, B.m., Torroni, A., et al. (1997). Differential structuring of human populations for homologous X and Y microsatellite loci. AMERICAN JOURNAL OF HUMAN GENETICS, 61(3), 719-733.
Scozzari, R; Cruciani, F; Malaspina, P; Santolamazza, P; Ciminelli, Bm; Torroni, A; Modiano, D; Wallace, D; Kidd, K; Olckers, A; Moral, P; Terrenato, ...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/44428
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