Terminal oligopyrimidine (TOP) mRNAs are a group of messengers translationally regulated according to the growth status of the cell. Two hypotheses have been proposed for the mechanism of the regulation: (i) there is a specific translational regulator which can reversibly alter TOP-mRNA structure, (ii) a component of the general translational apparatus can specifically affect the translation of TOP-mRNAs. To verify one of the two hypotheses we induced a partial inhibition of translation initiation in Xenopus cultured cells and analyzed the effect on TOP-mRNA translation. Our results suggest that a specific regulator is necessary to explain the translational control of these of mRNAs.
Loreni, F., & Amaldi, F. (1997). Translational control of terminal oligopyrimidine mRNAs requires a specific regulator. FEBS LETTERS, 416(3), 239-242.
Tipologia: | Articolo su rivista |
Citazione: | Loreni, F., & Amaldi, F. (1997). Translational control of terminal oligopyrimidine mRNAs requires a specific regulator. FEBS LETTERS, 416(3), 239-242. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore BIO/11 |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0014-5793(97)01209-X |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 1997 |
Titolo: | Translational control of terminal oligopyrimidine mRNAs requires a specific regulator |
Autori: | |
Autori: | Loreni, F; Amaldi, F |
Appare nelle tipologie: | 01 - Articolo su rivista |