BALB/c and severe combined immunodeficient (SCID) mice were inoculated intraperitoneally with Mycobacterium avium and the numbers of cfu were monitored for 70 days in spleen, liver, lung, kidney brain and peritoneum. While BALB/c mice formed typical granulomas and controlled bacterial growth in organs, a delay in development of lesions and a modest containment of infection were observed in SCID mice. In the spleen of BALB/c mice, in which bacterial growth was contained, macrophages (M phi) and natural killer (NK) cell numbers increased greater than or equal to 4.2 times and T- and B-cell numbers increased greater than or equal to 1.8 times after 42 days of infection; conversely, a low recruitment of mononuclear cells was observed in the spleen of SCID mice, where M. avinm proliferated efficiently. Unlike visceral organs, a pronounced decrease in the number of cfu was observed in the peritoneum of BALB/c mice, concomitantly with a greater than or equal to 31.7-fold increase in MB and NK cells and a greater than or equal to 9.1-fold increase in T and B cells. In the peritoneum of SCID mice only a bacteriostatic effect was observed despite a greater than or equal to 56.7-fold increase in Mo and NK cells and a greater than or equal to 22.3-fold increase in T and B cells. These results suggest that while an intact immune response can efficiently control M avium infection in the spleen and peritoneum of BALB/c mice, cells of the innate immune system such as Mo and NK cells play a role in the containment of bacterial growth in the peritoneum, but not spleen, of SCID mice.
Fattorini, L., Mattei, M., Placido, R., Li, B., Iona, E., Agrimi, U., et al. (1999). Mycobacterium avium infection in BALB c and SCID mice. JOURNAL OF MEDICAL MICROBIOLOGY, 48(6), 577-583.
|Tipologia:||Articolo su rivista|
|Citazione:||Fattorini, L., Mattei, M., Placido, R., Li, B., Iona, E., Agrimi, U., et al. (1999). Mycobacterium avium infection in BALB c and SCID mice. JOURNAL OF MEDICAL MICROBIOLOGY, 48(6), 577-583.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||1999|
|Titolo:||Mycobacterium avium infection in BALB c and SCID mice|
|Autori:||Fattorini, L; Mattei, M; Placido, R; Li, B; Iona, E; Agrimi, U; Colizzi, V; Orefici, G|
|Appare nelle tipologie:||01 - Articolo su rivista|