Herpes simplex viruses infect a variety of cells in vitro. However, not all infected cells sustain a fully productive replication of these viruses. We have shown that, in U937 monocytoid cells, herpes simplex virus 2 (HSV-2) causes a low-productive infection characterized by apoptosis as cytopathic effect at a late stage of infection. This effect was associated with a down-regulation of the Bcl-2 protein. We therefore asked whether destabilization of Bcl-2 expression could act as a limiting factor for the productive HSV-2 infection. We found that overexpression of Bcl-2 in U937 cells dramatically increased the capability of these cells to sustain a fully productive infection, while protecting against apoptosis induced by HSV-2. Overall, our data indicate that Bcl-2 expression acts as a regulator of HSV-2 replication. (c) 2006 Elsevier Inc. All rights reserved.

Sciortino M.T., P.D. (2006). Role of Bcl-2 expression for productive herpes simplex virus 2 replication. VIROLOGY, 356, 136-146 [10.1016/j.virol.2006.08.001].

Role of Bcl-2 expression for productive herpes simplex virus 2 replication

GRELLI, SANDRO;MASTINO, ANTONIO
2006-12

Abstract

Herpes simplex viruses infect a variety of cells in vitro. However, not all infected cells sustain a fully productive replication of these viruses. We have shown that, in U937 monocytoid cells, herpes simplex virus 2 (HSV-2) causes a low-productive infection characterized by apoptosis as cytopathic effect at a late stage of infection. This effect was associated with a down-regulation of the Bcl-2 protein. We therefore asked whether destabilization of Bcl-2 expression could act as a limiting factor for the productive HSV-2 infection. We found that overexpression of Bcl-2 in U937 cells dramatically increased the capability of these cells to sustain a fully productive infection, while protecting against apoptosis induced by HSV-2. Overall, our data indicate that Bcl-2 expression acts as a regulator of HSV-2 replication. (c) 2006 Elsevier Inc. All rights reserved.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - Microbiologia e Microbiologia Clinica
English
Con Impact Factor ISI
Apoptosis; Bcl-2; Herpes simplex; Virus infection; Virus replication
Sciortino M.T., P.D. (2006). Role of Bcl-2 expression for productive herpes simplex virus 2 replication. VIROLOGY, 356, 136-146 [10.1016/j.virol.2006.08.001].
Sciortino, Mt; Perri, D; Medici, Ma; Grelli, S; Serafino, A; Borner, C; Mastino, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/44019
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