The aim of this study was to investigate possible associations between the KCNJ11 rs2285676 and T2D susceptibility and/or clinical manifestations. The KCNJ11 rs2285676 genotypic/allelic distribution and the case/control association analysis were evaluated in one hundred and eighty-one T2D patients with type 2 diabetes (T2D), and one hundred and ninety-nine healthy controls. Our analyses showed a significant association between the presence of diabetic retinopathy (DR) and the variant allele of the SNV, both at the genotypic and at the allelic level. Our results indicate a possible involvement of the KCNJ11 gene in DR development and suggests that variants of this gene could help in the prediction of DR susceptibility.
Morgante, C., Latini, A., De Benedittis, G., Novelli, G., Spallone, V., Ciccacci, C., et al. (2025). A genetic variant in the potassium channel (KCNJ11) gene is associated with diabetic retinopathy in type 2 diabetes patients. GENE, 945 [10.1016/j.gene.2025.149289].
A genetic variant in the potassium channel (KCNJ11) gene is associated with diabetic retinopathy in type 2 diabetes patients
Morgante, Chiara;Latini, Andrea
;De Benedittis, Giada;Novelli, Giuseppe;Spallone, Vincenza;Ciccacci, Cinzia;Borgiani, Paola
2025-04-15
Abstract
The aim of this study was to investigate possible associations between the KCNJ11 rs2285676 and T2D susceptibility and/or clinical manifestations. The KCNJ11 rs2285676 genotypic/allelic distribution and the case/control association analysis were evaluated in one hundred and eighty-one T2D patients with type 2 diabetes (T2D), and one hundred and ninety-nine healthy controls. Our analyses showed a significant association between the presence of diabetic retinopathy (DR) and the variant allele of the SNV, both at the genotypic and at the allelic level. Our results indicate a possible involvement of the KCNJ11 gene in DR development and suggests that variants of this gene could help in the prediction of DR susceptibility.| File | Dimensione | Formato | |
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A genetic variant in the potassium channel (KCNJ11) gene is associated with diabetic retinopathy in type 2 diabetes patients.pdf
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