Contryphan-Vn is a D-tryptophan-containing disulfide-constrained nonapeptide isolated from the venom of Conus ventricosus, the single Mediterranean cone snail species. The structure of the synthetic Contryphan-Vn has been determined by NMR spectroscopy. Unique among Contryphans, Contryphan-Vn displays the peculiar presence of a Lys-Trp dyad, reminiscent of that observed in several voltage-gated K+ channel blockers. Electrophysiological experiments carried out on dorsal unpaired median neurons isolated from the cockroach (Periplaneta americana) nerve cord on rat fetal chromaffin cells indicate that Contryphan-Vn affects both voltage-gated and Ca2+-dependent K+ channel activities, with composite and diversified effects in invertebrate and vertebrate systems. Voltage-gated and Ca2+-dependent K+ channels represent the first functional target identified for a conopeptide of the Contryphan family. Furthermore, Contryphan-Vn is the first conopeptide known to modulate the activity of Ca2+-dependent K+ channels. © 2003 Elsevier Science (USA). All rights reserved.
Raybaudi Massilia, G., Eliseo, T., Grolleau, F., Lapied, B., Barbier, J., Bournaud, R., et al. (2003). Contryphan-Vn: A modulator of Ca2+-dependent K+ channels. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 303(1), 238-246.
Tipologia: | Articolo su rivista | |
Citazione: | Raybaudi Massilia, G., Eliseo, T., Grolleau, F., Lapied, B., Barbier, J., Bournaud, R., et al. (2003). Contryphan-Vn: A modulator of Ca2+-dependent K+ channels. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 303(1), 238-246. | |
IF: | Con Impact Factor ISI | |
Lingua: | English | |
Settore Scientifico Disciplinare: | Settore BIO/10 | |
Revisione (peer review): | Sì, ma tipo non specificato | |
Tipo: | Articolo | |
Rilevanza: | Rilevanza internazionale | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0006-291X(03)00331-0 | |
Stato di pubblicazione: | Pubblicato | |
Data di pubblicazione: | 2003 | |
Titolo: | Contryphan-Vn: A modulator of Ca2+-dependent K+ channels | |
Autori: | ||
Autori: | Raybaudi Massilia, G; Eliseo, T; Grolleau, F; Lapied, B; Barbier, J; Bournaud, R; Molgo, J; Cicero, DO; Paci, M; Schinina, ME; Ascenzi, P; Polticelli, F | |
Appare nelle tipologie: | 01 - Articolo su rivista |