Astroglial cells represent a target for HIV infection in the central nervous system. In astrocytes, HIV infection is poorly productive, being characterized by a persistent state of viral latency. However, activation of the nuclear factor NF-kappa B and its binding to HIV long terminal repeat (LTR) can induce HIV replication. Moreover, nitric oxide (NO) can affect NF-kappa B activation in glial cells. Therefore, we hypothesize that NO may reduce HIV replication in human astroglial cells by inhibiting HIV-1 LTR transcriptional activity. In this respect, we show that NO donors reduce viral replication in HIV-l-infected human astrocytoma T67 cells, taken as an astroglial model, Furthermore, using transfected T67 cells, we demonstrate that NO donors inhibit HIV-1 LTR transcriptional activity. These results suggest that the use of NO-releasing drugs may represent a potential, novel approach in inhibiting HIV replication in the central nervous system. (C) 1999 Academic Press.
Persichini, T., Colasanti, M., Fraziano, M., Colizzi, V., Ascenzi, P., & Lauro, G.M. (1999). Nitric oxide inhibits HIV-1 replication in human astrocytoma cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 254(1), 200-202.
Tipologia: | Articolo su rivista |
Citazione: | Persichini, T., Colasanti, M., Fraziano, M., Colizzi, V., Ascenzi, P., & Lauro, G.M. (1999). Nitric oxide inhibits HIV-1 replication in human astrocytoma cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 254(1), 200-202. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale Settore BIO/10 |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1006/bbrc.1998.9880 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 1999 |
Titolo: | Nitric oxide inhibits HIV-1 replication in human astrocytoma cells |
Autori: | |
Autori: | Persichini, T; Colasanti, M; Fraziano, M; Colizzi, V; Ascenzi, P; Lauro, GM |
Appare nelle tipologie: | 01 - Articolo su rivista |