Atrial natriuretic factor (ANF) is a polypeptide able to affect cardiovascular home-ostasis exhibiting diuretic, natriuretic, and vasorelaxant activities. ANF shows antimitogenic effects in different cell types acting through R-2 receptor. Excessive proliferation of smooth muscle cells is a common phenomenon in diseases such as atherosclerosis, but the role of growth factors in the mechanism which modulate this process has yet to be clarified. The potential antimitogenic role of ANF on the cell growth induced by growth factors appears very intriguing. Aim of the present study was to investigate the possible involvement of ANF on rat aortic smooth muscle (RASM) cells proliferation induced by known mitogens and the mechanism involved. Our data show that ANF, at physiological concentration range, inhibits RASM cell proliferation induced by known mitogens such as PDGF and insulin, and the effect seems to be elicited through the modulation of phosphatidic acid (PA) production and MAP kinases involvement. (C) 2002 Wiley-Liss, Inc.

Baldini, P.M., De Vito, P., Fraziano, M., Mattioli, P., Luly, P., & Di Nardo, P. (2002). Atrial natriuretic factor inhibits mitogen-induced growth in aortic smooth muscle cells. JOURNAL OF CELLULAR PHYSIOLOGY, 193(1), 103-109 [10.1002/jcp.10155].

Atrial natriuretic factor inhibits mitogen-induced growth in aortic smooth muscle cells

FRAZIANO, MAURIZIO;DI NARDO, PAOLO
2002

Abstract

Atrial natriuretic factor (ANF) is a polypeptide able to affect cardiovascular home-ostasis exhibiting diuretic, natriuretic, and vasorelaxant activities. ANF shows antimitogenic effects in different cell types acting through R-2 receptor. Excessive proliferation of smooth muscle cells is a common phenomenon in diseases such as atherosclerosis, but the role of growth factors in the mechanism which modulate this process has yet to be clarified. The potential antimitogenic role of ANF on the cell growth induced by growth factors appears very intriguing. Aim of the present study was to investigate the possible involvement of ANF on rat aortic smooth muscle (RASM) cells proliferation induced by known mitogens and the mechanism involved. Our data show that ANF, at physiological concentration range, inhibits RASM cell proliferation induced by known mitogens such as PDGF and insulin, and the effect seems to be elicited through the modulation of phosphatidic acid (PA) production and MAP kinases involvement. (C) 2002 Wiley-Liss, Inc.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/04 - Patologia Generale
Settore BIO/09
English
Con Impact Factor ISI
atrial natriuretic factor; animal cell; aorta media; article; astrocyte; cell growth; cell proliferation; cell type; endothelium cell; enzyme activation; enzyme specificity; growth inhibition; nonhuman; priority journal; rat; second messenger; smooth muscle fiber; target cell; Adrenergic beta-Antagonists; Animals; Aorta; Atenolol; Atrial Natriuretic Factor; Cell Cycle; Cell Division; Cells, Cultured; DNA; Flow Cytometry; Insulin; Male; Mitogens; Muscle, Smooth, Vascular; Phosphatidic Acids; Platelet-Derived Growth Factor; Rats; Rats, Wistar; Signal Transduction
Baldini, P.M., De Vito, P., Fraziano, M., Mattioli, P., Luly, P., & Di Nardo, P. (2002). Atrial natriuretic factor inhibits mitogen-induced growth in aortic smooth muscle cells. JOURNAL OF CELLULAR PHYSIOLOGY, 193(1), 103-109 [10.1002/jcp.10155].
Baldini, P; De Vito, P; Fraziano, M; Mattioli, P; Luly, P; DI NARDO, P
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/43551
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact