Two polymorphic sites, -107 C --> T and -100 G --> C with respect to the cap site of the human beta pseudogene of the hemoglobin gene, are described. They have been studied in five European, one Indian, two Asian, and two sub-Saharan African populations. The -107 C -->T site turned out to be polymorphic in all five European populations and the Indian population (pooled q = 0.142 +/- 0.018) and in the two Asian populations (pooled q = 0.073 +/- 0.025), but it was monomorphic in the two sub-Saharan populations. On the contrary, the -100 G --> C site was polymorphic in the two sub-Saharan samples (q = 0.093 +/- 0.024), but the variant allele was not found in any of the European, Indian, or Asian samples. Thus this only g-bp-long stretch of DNA is informative for estimating the extent of genetic admixture in sub-Saharan Africans.

Pompei, F., Ciminelli, B.m., Modiano, G. (1998). Two ethnic-specific polymorphisms in the human beta pseudogene of hemoglobin. HUMAN BIOLOGY, 70(4), 659-666.

Two ethnic-specific polymorphisms in the human beta pseudogene of hemoglobin

CIMINELLI, BIANCA MARIA;MODIANO, GUIDO
1998-01-01

Abstract

Two polymorphic sites, -107 C --> T and -100 G --> C with respect to the cap site of the human beta pseudogene of the hemoglobin gene, are described. They have been studied in five European, one Indian, two Asian, and two sub-Saharan African populations. The -107 C -->T site turned out to be polymorphic in all five European populations and the Indian population (pooled q = 0.142 +/- 0.018) and in the two Asian populations (pooled q = 0.073 +/- 0.025), but it was monomorphic in the two sub-Saharan populations. On the contrary, the -100 G --> C site was polymorphic in the two sub-Saharan samples (q = 0.093 +/- 0.024), but the variant allele was not found in any of the European, Indian, or Asian samples. Thus this only g-bp-long stretch of DNA is informative for estimating the extent of genetic admixture in sub-Saharan Africans.
1998
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/18 - GENETICA
English
Con Impact Factor ISI
Discriminatory anthropogenetic markers; DNA polymorphic sites; Haplotypes; Sub-Saharan Africans
Pompei, F., Ciminelli, B.m., Modiano, G. (1998). Two ethnic-specific polymorphisms in the human beta pseudogene of hemoglobin. HUMAN BIOLOGY, 70(4), 659-666.
Pompei, F; Ciminelli, Bm; Modiano, G
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/43118
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact