Myelin plasticity is a key process for acquiring new motor skills and preventing neurodegeneration during ageing. Neural precursor cells (NPCs) and parenchymal oligodendrocyte precursor cells (OPCs) play a key role in myelin plasticity in the central nervous system (CNS), being specialized in reconstituting the myelin sheath upon damage. Reversible acetylation, regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) activity, controls these stem cells' differentiation in myelinating oligodendrocytes (mOLs) during their proliferation and remyelination processes. By modulating cytosolic protein activity and precisely orchestrating the spatial and timely regulated activity of the transcription factors participating in the NPC and OPC differentiation process, these enzymes play a vital role in preserving the adult brain's cognitive capacity during ageing. This review highlights the role of reversible acetylation in the regulation of stem cell differentiation during remyelination, as disruptions in this process contribute to severe neurodegenerative impairments and accelerated ageing.
Dominicis, A., Fabiano, T., Peria, S., Al Jaf, A., Ragnini, A. (2025). Impact of Histone Acetyltransferases and Histone Deacetylases on Adult Brain Myelin Plasticity. In M. Halasa (a cura di), Histone and Non-Histone Reversible Acetylation in Development, Aging and Disease (pp. 213-246). New York : SpringerNature [10.1007/978-3-031-91459-1_8].
Impact of Histone Acetyltransferases and Histone Deacetylases on Adult Brain Myelin Plasticity
Alessandra DominicisInvestigation
;Tommaso FabianoInvestigation
;Aland Ibrahim Ahmed Al JafInvestigation
;Antonella Ragnini
Conceptualization
2025-07-02
Abstract
Myelin plasticity is a key process for acquiring new motor skills and preventing neurodegeneration during ageing. Neural precursor cells (NPCs) and parenchymal oligodendrocyte precursor cells (OPCs) play a key role in myelin plasticity in the central nervous system (CNS), being specialized in reconstituting the myelin sheath upon damage. Reversible acetylation, regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) activity, controls these stem cells' differentiation in myelinating oligodendrocytes (mOLs) during their proliferation and remyelination processes. By modulating cytosolic protein activity and precisely orchestrating the spatial and timely regulated activity of the transcription factors participating in the NPC and OPC differentiation process, these enzymes play a vital role in preserving the adult brain's cognitive capacity during ageing. This review highlights the role of reversible acetylation in the regulation of stem cell differentiation during remyelination, as disruptions in this process contribute to severe neurodegenerative impairments and accelerated ageing.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
