Acetyl-L-carnitine (ALC) plays a relevant role in energy metabolism and stress response because of its function in the complex metabolic system regulating the acetyl-CoA levels that provide a source of acetyl groups for metabolic and acetylation-regulated processes. Because acetylation may influence p53 activity/stability and, therefore, the response to platinum compounds, this study was designed to investigate the effect of ALC in combination with platinum compounds.

Pisano, C., Vesci, L., Milazzo, F., Guglielmi, M., Foderà, R., Barbarino, M., et al. (2010). Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine. CLINICAL CANCER RESEARCH, 16(15), 3944-3953 [10.1158/1078-0432.CCR-10-0964].

Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine

ORLANDI, AUGUSTO;
2010-08-01

Abstract

Acetyl-L-carnitine (ALC) plays a relevant role in energy metabolism and stress response because of its function in the complex metabolic system regulating the acetyl-CoA levels that provide a source of acetyl groups for metabolic and acetylation-regulated processes. Because acetylation may influence p53 activity/stability and, therefore, the response to platinum compounds, this study was designed to investigate the effect of ALC in combination with platinum compounds.
1-ago-2010
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/08 - ANATOMIA PATOLOGICA
English
Con Impact Factor ISI
Animals; Tumor Suppressor Protein p53; Apoptosis; Humans; Mice, Nude; Mice; Cell Line, Tumor; Carboplatin; Reverse Transcriptase Polymerase Chain Reaction; In Situ Nick-End Labeling; Blotting, Western; Cisplatin; Lung Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Xenograft Model Antitumor Assays; Carcinoma, Non-Small-Cell Lung; Histone Deacetylase Inhibitors; Male; Female; Acetylcarnitine
Pisano, C., Vesci, L., Milazzo, F., Guglielmi, M., Foderà, R., Barbarino, M., et al. (2010). Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine. CLINICAL CANCER RESEARCH, 16(15), 3944-3953 [10.1158/1078-0432.CCR-10-0964].
Pisano, C; Vesci, L; Milazzo, F; Guglielmi, M; Foderà, R; Barbarino, M; D'Incalci, M; Zucchetti, M; Petrangolini, G; Tortoreto, M; Perego, P; Zuco, V...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/42347
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