Expression of appetite or the motivational drive toward an energy source is a highly regulated phenomenon in vertebrates. In humans, energy intake is not influenced solely by nutritional needs but also by emotional, social and cultural factors; however, over the long-term the cumulative match between energy expenditure and energy intake is tuned with high precision (Edholm, 1977). This phenomenon reflects an active regulatory process, termed energy homeostasis, that promotes stability in the amount of body energy stored in the form of fat, and it is considered essential for rigidly guarding the body weight around a set point. Abnormalities in the onset, periodicity, duration and magnitude of eating episodes generally underlie augmented appetite (Stunkard, 1996; Bray et al., 1990). Increased appetite, whether temporary, as seen clinically in transient bingeing, or permanent, invariably culminates in an increased rate of body weight gain and obesity (Kalra, 1997; Wadden, 1993; Perri et al., 1993; Bray, 1996). On the other hand, anorexia due to psychobiological causes (Stewart-Agras et al., 1984; Crisp, 1984) or in response to acute and chronic infections, inflammation and trauma is followed by severe loss of body weight (Moldawer et al., 1988; Plata-Salaman et al., 1991; Grunfeld et al., 1992).

Sbraccia, P., D'Adamo, M., Lauro, R. (2004). Obesity and anorexia as neuroendocrine disorders.. In C.F. Baldelli R (a cura di), Update in Neuroendocrinology. Pubblicazioni Medico Scientifiche.

Obesity and anorexia as neuroendocrine disorders.

SBRACCIA, PAOLO;D'ADAMO, MONICA;LAURO, RENATO
2004-07-01

Abstract

Expression of appetite or the motivational drive toward an energy source is a highly regulated phenomenon in vertebrates. In humans, energy intake is not influenced solely by nutritional needs but also by emotional, social and cultural factors; however, over the long-term the cumulative match between energy expenditure and energy intake is tuned with high precision (Edholm, 1977). This phenomenon reflects an active regulatory process, termed energy homeostasis, that promotes stability in the amount of body energy stored in the form of fat, and it is considered essential for rigidly guarding the body weight around a set point. Abnormalities in the onset, periodicity, duration and magnitude of eating episodes generally underlie augmented appetite (Stunkard, 1996; Bray et al., 1990). Increased appetite, whether temporary, as seen clinically in transient bingeing, or permanent, invariably culminates in an increased rate of body weight gain and obesity (Kalra, 1997; Wadden, 1993; Perri et al., 1993; Bray, 1996). On the other hand, anorexia due to psychobiological causes (Stewart-Agras et al., 1984; Crisp, 1984) or in response to acute and chronic infections, inflammation and trauma is followed by severe loss of body weight (Moldawer et al., 1988; Plata-Salaman et al., 1991; Grunfeld et al., 1992).
1-lug-2004
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
Settore MED/09 - MEDICINA INTERNA
English
Rilevanza internazionale
Capitolo o saggio
Obesity, neuroendocrinology, anorexia
Sbraccia, P., D'Adamo, M., Lauro, R. (2004). Obesity and anorexia as neuroendocrine disorders.. In C.F. Baldelli R (a cura di), Update in Neuroendocrinology. Pubblicazioni Medico Scientifiche.
Sbraccia, P; D'Adamo, M; Lauro, R
Contributo in libro
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/42221
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact