Background: Functional alterations of the autonomic nervous system have been described in relation to chronic hypoxemia in chronic obstructive pulmonary diseases. Aim of the present study was to investigate the occurrence of neuro-vegetative dysfunction during active tuberculosis in the absence of hypoxemia. Materials and methods: Fifteen patients affected by pulmonary tuberculosis under standard therapy and 17 matched controls were enrolled. Activation of the sympathetic system was induced by the tilt-up test. Systolic and diastolic arterial pressures and the R-R interval were monitored for 15 min by Finapres and ECG. The baroreflex sensitivity was evaluated by the spontaneous sequences method. Results: Systolic and diastolic pressures were significantly higher at basal conditions and showed a less increase during the tilt test in tuberculosis patients compared to healthy controls. The basal R-R interval was shorter and its reduction during the tilt test was less evident in patients. The baroreflex sensitivity was decreased in patients at basal conditions and its reduction during the tilt test was less evident than in controls. Conclusions: Our preliminary results suggest the presence in tuberculosis patients of an altered autonomic cardiovascular regulation, which is a reduced function of the baroreflex control of-the sinus node. (c) 2007 Elsevier Ltd. All rights reserved.
Raimondi G., C.S. (2007). Autonomic nervous system dysfunction in the course of active pulmonary tuberculosis. RESPIRATORY MEDICINE, 101(8), 1804-1808.
|Tipologia:||Articolo su rivista|
|Citazione:||Raimondi G., C.S. (2007). Autonomic nervous system dysfunction in the course of active pulmonary tuberculosis. RESPIRATORY MEDICINE, 101(8), 1804-1808.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/10 - Malattie dell'Apparato Respiratorio|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.rmed.2007.02.008|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2007|
|Titolo:||Autonomic nervous system dysfunction in the course of active pulmonary tuberculosis|
|Autori:||Raimondi G., Contini S., Maria Legramante J., Bocchino M., Sacco S., Pallante M., Cazzola M., Saltini C.|
|Appare nelle tipologie:||01 - Articolo su rivista|