Airway smooth muscle (ASM) plays a key rote in bronchomotor tone, as well as in structural remodeling of the bronchial wall. Therefore, ASM contraction and proliferation significantly participate in the development and progression of asthma. Many contractile agonists also behave as mitogenic stimuli, thus contributing to frame a hyperresponsive and hyperplastic ASM phenotype. In this review, the molecular mechanisms and signaling pathways involved in excitation-contraction coupling and ASM cell growth will be outlined. Indeed, the recent advances in understanding the basic aspects of ASM biology are disclosing important cellular targets, currently explored for the implementation of new, more effective anti-asthma therapies. (C) 2008 Published by Elsevier Ltd.

Pelaia, G., Renda, T., Gallelli, L., Vatrella, A., Busceti, M., Agati, S., et al. (2008). Molecular mechanisms underlying airway smooth muscle contraction and proliferation: implications for asthma. RESPIRATORY MEDICINE, 102(8), 1173-1181 [10.1016/j.rmed.2008.02.020].

Molecular mechanisms underlying airway smooth muscle contraction and proliferation: implications for asthma

CAZZOLA, MARIO;
2008-01-01

Abstract

Airway smooth muscle (ASM) plays a key rote in bronchomotor tone, as well as in structural remodeling of the bronchial wall. Therefore, ASM contraction and proliferation significantly participate in the development and progression of asthma. Many contractile agonists also behave as mitogenic stimuli, thus contributing to frame a hyperresponsive and hyperplastic ASM phenotype. In this review, the molecular mechanisms and signaling pathways involved in excitation-contraction coupling and ASM cell growth will be outlined. Indeed, the recent advances in understanding the basic aspects of ASM biology are disclosing important cellular targets, currently explored for the implementation of new, more effective anti-asthma therapies. (C) 2008 Published by Elsevier Ltd.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/10 - Malattie dell'Apparato Respiratorio
English
Con Impact Factor ISI
airway smooth muscle; asthma; contraction; proliferation
Pelaia, G., Renda, T., Gallelli, L., Vatrella, A., Busceti, M., Agati, S., et al. (2008). Molecular mechanisms underlying airway smooth muscle contraction and proliferation: implications for asthma. RESPIRATORY MEDICINE, 102(8), 1173-1181 [10.1016/j.rmed.2008.02.020].
Pelaia, G; Renda, T; Gallelli, L; Vatrella, A; Busceti, M; Agati, S; Caputi, M; Cazzola, M; Maselli, R; Marsico, S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/42150
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