COPD is an increasing health problem and one of the leading causes of morbidity and mortality worldwide, but knowledge about its pathogenesis has increased substantially in recent years. The disease results from interaction between individual risk factors (like enzymatic deficiencies) and environmental exposures to noxious agents, like cigarette smoking, occupational dusts, air pollution and infections in childhood. The main mechanisms that may contribute to airflow limitation in COPD are fixed narrowing of small airways, emphysema and luminal obstruction with mucus secretions. COPD is characterized by a chronic inflammatory process in the pulmonary tissue, with a pattern different from bronchial asthma, associated with extra pulmonary effects and is considered now a complex, systemic disease. Optimal therapeutic targeting of COPD depends on a clear understanding of the precise mechanisms of these complex processes and on early and correct evaluation of disease severity. A combination of pharmacological and non-pharmacological approaches is used to treat COPD. Bronchodilators are the mainstay of COPD treatment and can be combined with inhaled corticosteroids for greater efficacy and fewer side effects. The use of LTOT for hypoxemic patients has resulted in increased survival, and expanded drug therapy options have effectively improved dyspnoea and quality of life. Recent studies have documented the benefits of pulmonary rehabilitation. In addition, noninvasive mechanical ventilation offers new alternatives for patients with acute or chronic failure.

Cazzola, M., Donner, C., & Hanania, N.A. (2008). One hundred years of respiratory medicine chronic obstructive pulmonary disease (COPD). Republished article. RESPIRATORY MEDICINE, 4(1), 8-25 [10.1016/j.rmedu.2007.11.019].

One hundred years of respiratory medicine chronic obstructive pulmonary disease (COPD). Republished article

CAZZOLA, MARIO;
2008

Abstract

COPD is an increasing health problem and one of the leading causes of morbidity and mortality worldwide, but knowledge about its pathogenesis has increased substantially in recent years. The disease results from interaction between individual risk factors (like enzymatic deficiencies) and environmental exposures to noxious agents, like cigarette smoking, occupational dusts, air pollution and infections in childhood. The main mechanisms that may contribute to airflow limitation in COPD are fixed narrowing of small airways, emphysema and luminal obstruction with mucus secretions. COPD is characterized by a chronic inflammatory process in the pulmonary tissue, with a pattern different from bronchial asthma, associated with extra pulmonary effects and is considered now a complex, systemic disease. Optimal therapeutic targeting of COPD depends on a clear understanding of the precise mechanisms of these complex processes and on early and correct evaluation of disease severity. A combination of pharmacological and non-pharmacological approaches is used to treat COPD. Bronchodilators are the mainstay of COPD treatment and can be combined with inhaled corticosteroids for greater efficacy and fewer side effects. The use of LTOT for hypoxemic patients has resulted in increased survival, and expanded drug therapy options have effectively improved dyspnoea and quality of life. Recent studies have documented the benefits of pulmonary rehabilitation. In addition, noninvasive mechanical ventilation offers new alternatives for patients with acute or chronic failure.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/10 - Malattie dell'Apparato Respiratorio
English
Con Impact Factor ISI
chronic bronchitis; COPD; emphysema
Cazzola, M., Donner, C., & Hanania, N.A. (2008). One hundred years of respiratory medicine chronic obstructive pulmonary disease (COPD). Republished article. RESPIRATORY MEDICINE, 4(1), 8-25 [10.1016/j.rmedu.2007.11.019].
Cazzola, M; Donner, C; Hanania, N
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/42143
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