Weight gain is associated with a decline in insulin sensitivity and a compensatory increase in insulin secretion. IGF-1 is a plausible candidate to explain these divergent phenomena. In this cross-sectional study, we analyzed the relationship between IGF-1 levels, insulin sensitivity and secretion in 110 nondiabetic subjects with a wide range of BMI to verify this hypothesis.

Succurro, E., Andreozzi, F., Marini, M.a., Lauro, R., Hribal, M., Perticone, F., et al. (2009). Low plasma insulin-like growth factor-1 levels are associated with reduced insulin sensitivity and increased insulin secretion in nondiabetic subjects. NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 19(10), 713-719 [10.1016/j.numecd.2008.12.011].

Low plasma insulin-like growth factor-1 levels are associated with reduced insulin sensitivity and increased insulin secretion in nondiabetic subjects

MARINI, MARIA ADELAIDE;LAURO, RENATO;
2009-12-01

Abstract

Weight gain is associated with a decline in insulin sensitivity and a compensatory increase in insulin secretion. IGF-1 is a plausible candidate to explain these divergent phenomena. In this cross-sectional study, we analyzed the relationship between IGF-1 levels, insulin sensitivity and secretion in 110 nondiabetic subjects with a wide range of BMI to verify this hypothesis.
dic-2009
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/09 - MEDICINA INTERNA
English
Con Impact Factor ISI
Blood Glucose; Male; European Continental Ancestry Group; Young Adult; Middle Aged; Female; Overweight; Insulin Resistance; Humans; Insulin-Like Growth Factor I; Triglycerides; Insulin; Glucose Clamp Technique; Obesity; Body Mass Index; Adiposity; Glucose Tolerance Test; Cross-Sectional Studies; Aged; Adult; Aging
Succurro, E., Andreozzi, F., Marini, M.a., Lauro, R., Hribal, M., Perticone, F., et al. (2009). Low plasma insulin-like growth factor-1 levels are associated with reduced insulin sensitivity and increased insulin secretion in nondiabetic subjects. NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 19(10), 713-719 [10.1016/j.numecd.2008.12.011].
Succurro, E; Andreozzi, F; Marini, Ma; Lauro, R; Hribal, M; Perticone, F; Sesti, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/41921
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