Epidemiological studies have suggested an association between vitamin C (and other antioxidant vitamins) and cancer risk. However, the mechanisms accounting for prevention have not been extensively investigated. In skin, vitamin C (ascorbic acid) exerts different biological roles, including photoprotective effects and participation in collagen synthesis. This paper reports new findings about additional functions of the vitamin. Vitamin C counteracts oxidative stress via transcriptional and post-translational mechanisms; this modulation may interfere with the activity of redox-sensitive transcription factors, commitment to differentiation or cell cycle arrest, and apoptosis in response to DNA damage. All of these vitamin C-mediated responses might be important in different cell types, allowing for the maintenance of body homeostasis. © 2005 International Life Sciences Institute.
Catani, M.V., Savini, I., Rossi, A., Melino, G., & Avigliano, L. (2005). Biological role of vitamin C in keratinocytes. NUTRITION REVIEWS, 63(3), 81-90.
Tipologia: | Articolo su rivista |
Citazione: | Catani, M.V., Savini, I., Rossi, A., Melino, G., & Avigliano, L. (2005). Biological role of vitamin C in keratinocytes. NUTRITION REVIEWS, 63(3), 81-90. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore MED/49 - Scienze Tecniche Dietetiche Applicate |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1301/nr.2005.mar.000-000 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2005 |
Titolo: | Biological role of vitamin C in keratinocytes |
Autori: | |
Autori: | Catani, MV; Savini, I; Rossi, A; Melino, G; Avigliano, L |
Appare nelle tipologie: | 01 - Articolo su rivista |