Targeting is a main feature supporting any controlled drug delivery modality. Recently we developed poly(vinyl alcohol), PVA, based microbubbles as a potential new ultrasound contrast agent featuring an efficient ultrasound backscattering and a good shelf stability. The chemical versatility of the polymeric surface of this device offers a vast variety of coupling modalities useful for coating and specific targeting. We have designed a conjugation strategy on PVA shelled microbubbles to enable the localization and the drug delivery on tumor cells by modifying the surface of this polymeric ultrasound contrast agent (UCA) with oxidized hyaluronic acid (HAox). After the conversion of the microbubbles into microcapsules, the kinetics of the release of doxorubicin, a well-known antitumor drug, from uncoated and HAox-coated PVA microbubbles and microcapsules was investigated. Cytocompatibility and bioadhesive properties of the HA-modified microparticles were then tested on the HT-29 tumor cell line. Cytotoxicity to HT-29 tumor cells of microcapsules after loading with doxorubicin was studied, evidencing the efficacy of the HAox coating for the delivery of the drug to cells. These features are a prerequisite for a theranostic, that is, diagnostic and therapeutic, use of polymer-based UCAs.

Chiessi, E., Cerroni, B., Margheritelli, S., Oddo, L., Paradossi, G. (2011). Polymer Shelled Microparticles for a Targeted Doxorubicin Delivery in Cancer Therapy. BIOMACROMOLECULES, 12(3), 593-601 [10.1021/bm101207k].

Polymer Shelled Microparticles for a Targeted Doxorubicin Delivery in Cancer Therapy

CHIESSI, ESTER;CERRONI, BARBARA;ODDO, LETIZIA;PARADOSSI, GAIO
2011-01-01

Abstract

Targeting is a main feature supporting any controlled drug delivery modality. Recently we developed poly(vinyl alcohol), PVA, based microbubbles as a potential new ultrasound contrast agent featuring an efficient ultrasound backscattering and a good shelf stability. The chemical versatility of the polymeric surface of this device offers a vast variety of coupling modalities useful for coating and specific targeting. We have designed a conjugation strategy on PVA shelled microbubbles to enable the localization and the drug delivery on tumor cells by modifying the surface of this polymeric ultrasound contrast agent (UCA) with oxidized hyaluronic acid (HAox). After the conversion of the microbubbles into microcapsules, the kinetics of the release of doxorubicin, a well-known antitumor drug, from uncoated and HAox-coated PVA microbubbles and microcapsules was investigated. Cytocompatibility and bioadhesive properties of the HA-modified microparticles were then tested on the HT-29 tumor cell line. Cytotoxicity to HT-29 tumor cells of microcapsules after loading with doxorubicin was studied, evidencing the efficacy of the HAox coating for the delivery of the drug to cells. These features are a prerequisite for a theranostic, that is, diagnostic and therapeutic, use of polymer-based UCAs.
2011
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore CHIM/02 - CHIMICA FISICA
English
Con Impact Factor ISI
polymer hydrogel; ultrasound contrast agent; drug delivery
Chiessi, E., Cerroni, B., Margheritelli, S., Oddo, L., Paradossi, G. (2011). Polymer Shelled Microparticles for a Targeted Doxorubicin Delivery in Cancer Therapy. BIOMACROMOLECULES, 12(3), 593-601 [10.1021/bm101207k].
Chiessi, E; Cerroni, B; Margheritelli, S; Oddo, L; Paradossi, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/41621
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