The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H(2)O(2) treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H(2)O(2)-induced mitochondrial alterations.

Cerella, C., Coppola, S., Maresca, V., De Nicola, M., Radogna, F., Ghibelli, L. (2009). Multiple mechanisms for hydrogen peroxide-induced apoptosis. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1171, 559-563 [10.1111/j.1749-6632.2009.04901.x].

Multiple mechanisms for hydrogen peroxide-induced apoptosis

GHIBELLI, LINA
2009-08-01

Abstract

The mechanisms of cell killing by oxidative stress, in particular by hydrogen peroxide, are not yet well clarified. Here, we show that during recovery after H(2)O(2) treatment, apoptosis occurs in two different waves, peaking at 8 h (early) and 18 h (late) of recovery from oxidative stress. The two peaks are differentially modulated by a set of inhibitors of metabolic processes, which suggests that the first peak depends on DNA break formation, whereas the second may be correlated with H(2)O(2)-induced mitochondrial alterations.
ago-2009
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/13 - BIOLOGIA APPLICATA
English
Con Impact Factor ISI
Time Factors; Apoptosis; Microscopy, Fluorescence; Guanidines; 3-Iodobenzylguanidine; Oxidants; Deoxyglucose; Benzamides; DNA Fragmentation; U937 Cells; Hydrogen Peroxide; Humans
Cerella, C., Coppola, S., Maresca, V., De Nicola, M., Radogna, F., Ghibelli, L. (2009). Multiple mechanisms for hydrogen peroxide-induced apoptosis. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1171, 559-563 [10.1111/j.1749-6632.2009.04901.x].
Cerella, C; Coppola, S; Maresca, V; De Nicola, M; Radogna, F; Ghibelli, L
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/41552
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 27
  • ???jsp.display-item.citation.isi??? 26
social impact