Tumor cells often develop molecular strategies for survival to anoxia/reoxygenation stress as part of tumor progression. Here we describe that the B lymphoma Epstein-Barr-positive cells E2r survive reoxygenation in spite of a very high and long-lasting increase in cytosolic Ca2+ and the loss of about half of their mitochondria due to specific extrusion of the organelles from the cells. The extrusion typically occurs 3 days after reoxygenation, and a regular mitochondrial asset is regained after further 24 h.

Dorio, A., Cerella, C., De Nicola, M., D'Alessio, M., Gualandi, G., Ghibelli, L. (2007). Non-apoptogenic Ca2+-related extrusion of mitochondria in anoxia/reoxygenation stress. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1099, 512-515 [10.1196/annals.1387.067].

Non-apoptogenic Ca2+-related extrusion of mitochondria in anoxia/reoxygenation stress

GHIBELLI, LINA
2007-03-01

Abstract

Tumor cells often develop molecular strategies for survival to anoxia/reoxygenation stress as part of tumor progression. Here we describe that the B lymphoma Epstein-Barr-positive cells E2r survive reoxygenation in spite of a very high and long-lasting increase in cytosolic Ca2+ and the loss of about half of their mitochondria due to specific extrusion of the organelles from the cells. The extrusion typically occurs 3 days after reoxygenation, and a regular mitochondrial asset is regained after further 24 h.
mar-2007
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/13 - BIOLOGIA APPLICATA
English
Con Impact Factor ISI
Cell Line, Tumor; Cell Proliferation; Apoptosis; Oxygen; Calcium; Mitochondria; Humans
Dorio, A., Cerella, C., De Nicola, M., D'Alessio, M., Gualandi, G., Ghibelli, L. (2007). Non-apoptogenic Ca2+-related extrusion of mitochondria in anoxia/reoxygenation stress. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1099, 512-515 [10.1196/annals.1387.067].
Dorio, A; Cerella, C; De Nicola, M; D'Alessio, M; Gualandi, G; Ghibelli, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/41538
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