Abnormal connectivity might be involved in the pathophysiology of Tuberous Sclerosis Complex (TSC). We used twin-coil Transcranial Magnetic Stimulation protocol to investigate connectivity between posterior parietal cortex (PPC) and motor cortex (M1) in TSC patients. In comparison with healthy subjects and TSC patients treated with antiepileptic drugs, non-medicated TSC patients exhibited abnormal excitability of PPC-M1 connection. Such altered connectivity might play a role in TSC epileptic phenotype.

D'Argenzio, L., Koch, G., Bombardieri, R., Mori, F., Moavero, R., Centonze, D., et al. (2009). Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex. EPILEPSY RESEARCH, 87(1), 102-105 [10.1016/j.eplepsyres.2009.07.009].

Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex

MOAVERO, ROMINA;CENTONZE, DIEGO;CURATOLO, PAOLO
2009-11-01

Abstract

Abnormal connectivity might be involved in the pathophysiology of Tuberous Sclerosis Complex (TSC). We used twin-coil Transcranial Magnetic Stimulation protocol to investigate connectivity between posterior parietal cortex (PPC) and motor cortex (M1) in TSC patients. In comparison with healthy subjects and TSC patients treated with antiepileptic drugs, non-medicated TSC patients exhibited abnormal excitability of PPC-M1 connection. Such altered connectivity might play a role in TSC epileptic phenotype.
nov-2009
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/26 - NEUROLOGIA
English
Con Impact Factor ISI
Signal Processing, Computer-Assisted; Analysis of Variance; Adolescent; Male; Tuberous Sclerosis; Middle Aged; Electromyography; Female; Evoked Potentials, Motor; Electric Stimulation; Humans; Motor Cortex; Parietal Lobe; Neural Pathways; Transcranial Magnetic Stimulation; Brain Mapping; Adult
D'Argenzio, L., Koch, G., Bombardieri, R., Mori, F., Moavero, R., Centonze, D., et al. (2009). Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex. EPILEPSY RESEARCH, 87(1), 102-105 [10.1016/j.eplepsyres.2009.07.009].
D'Argenzio, L; Koch, G; Bombardieri, R; Mori, F; Moavero, R; Centonze, D; Curatolo, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/41442
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