: We report a young patient harboring a RHOBTB2 likely pathogenic variant with recurrent episodes of headache, dysautonomia and hemiplegia consistent with hemiplegic migraine. Such episodes were responsive to flunarizine prophylaxis. Ictal MRI showed contralateral hemispheric hypoperfusion. This report expands RHOBTB2 spectrum to include hemiplegic migraine and provides insight into the pathophysiology of hemiplegic attacks in this condition.
Innocenti, A., Garone, G., Papetti, L., Rossi Espagnet, C., Carboni, A., Parisi, P., et al. (2025). RHOBTB2-related paroxysmal hemiparesis: From alternating hemiplegia to hemiplegic migraine. PARKINSONISM & RELATED DISORDERS, 133 [10.1016/j.parkreldis.2025.107340].
RHOBTB2-related paroxysmal hemiparesis: From alternating hemiplegia to hemiplegic migraine
Garone, Giacomo;Valeriani, Massimiliano;
2025-02-14
Abstract
: We report a young patient harboring a RHOBTB2 likely pathogenic variant with recurrent episodes of headache, dysautonomia and hemiplegia consistent with hemiplegic migraine. Such episodes were responsive to flunarizine prophylaxis. Ictal MRI showed contralateral hemispheric hypoperfusion. This report expands RHOBTB2 spectrum to include hemiplegic migraine and provides insight into the pathophysiology of hemiplegic attacks in this condition.| File | Dimensione | Formato | |
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