123I-FP-CIT SPECT binding to striatal dopamine transporter (DAT) is markedly reduced in patients with Parkinson's disease (PD) and it may also help in identifyng pre-symptomatic nigrostriatal dysfunction in subjects at risk. This study used semi-quantitative analysis of 123I-FP-CIT SPECT to evaluate the possibility of a more extensive and earlier diagnosis of dopaminergic damage. We used qualitative visual assessment and semi-quantitative measures of striatal DAT binding using 123I-FP-CIT SPECT in 154 patients with suspected PD. A control group comprised 18 people age-matched to the PD group whose follow-up disclosed essential tremor. Abnormal striatal 123I-FP-CIT uptake was evident in 134 out of 154 patients (87%). Qualitative visual assessment showed striatal dopaminergic 123I-FP-CIT uptake was significantly reduced in 60.4% (controlateral putamen to the symptoms), in 31.3% (caudate nucleus) and in 8.3% (ipsolateral basal ganglia to the symptoms). Semi-quantitative analysis showed the following results: 32.8%, 50.7% and 16.5% respectively. We compared these two assessments and their correlation with PD clinical progression. At 24 month follow-up, patients with greater dopaminergic damage at semiquantitative analysis showed a more severe motor disability. Our findings indicate that 123-FP-CIT SPECT with semiquantitative analysis can offer a more accurate characterization of the dopaminergic damage in patients with suspected Parkinson's disease.
Filippi, L., Bruni, C., Padovano, F., Schillaci, O., & Simonetti, G. (2008). The value of semi-quantitative analysis of 123I-FP-CIT SPECT in evaluating patients with parkinson's disease. THE NEURORADIOLOGY JOURNAL, 21(4), 505-509.
|Tipologia:||Articolo su rivista|
|Citazione:||Filippi, L., Bruni, C., Padovano, F., Schillaci, O., & Simonetti, G. (2008). The value of semi-quantitative analysis of 123I-FP-CIT SPECT in evaluating patients with parkinson's disease. THE NEURORADIOLOGY JOURNAL, 21(4), 505-509.|
|Settore Scientifico Disciplinare:||Settore MED/50 - Scienze Tecniche Mediche Applicate|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2008|
|Titolo:||The value of semi-quantitative analysis of 123I-FP-CIT SPECT in evaluating patients with parkinson's disease|
|Autori:||Filippi,L; Bruni,C; Padovano,F; Schillaci,O; Simonetti, GME|
|Appare nelle tipologie:||01 - Articolo su rivista|