123I-FP-CIT SPECT binding to striatal dopamine transporter (DAT) is markedly reduced in patients with Parkinson's disease (PD) and it may also help in identifyng pre-symptomatic nigrostriatal dysfunction in subjects at risk. This study used semi-quantitative analysis of 123I-FP-CIT SPECT to evaluate the possibility of a more extensive and earlier diagnosis of dopaminergic damage. We used qualitative visual assessment and semi-quantitative measures of striatal DAT binding using 123I-FP-CIT SPECT in 154 patients with suspected PD. A control group comprised 18 people age-matched to the PD group whose follow-up disclosed essential tremor. Abnormal striatal 123I-FP-CIT uptake was evident in 134 out of 154 patients (87%). Qualitative visual assessment showed striatal dopaminergic 123I-FP-CIT uptake was significantly reduced in 60.4% (controlateral putamen to the symptoms), in 31.3% (caudate nucleus) and in 8.3% (ipsolateral basal ganglia to the symptoms). Semi-quantitative analysis showed the following results: 32.8%, 50.7% and 16.5% respectively. We compared these two assessments and their correlation with PD clinical progression. At 24 month follow-up, patients with greater dopaminergic damage at semiquantitative analysis showed a more severe motor disability. Our findings indicate that 123-FP-CIT SPECT with semiquantitative analysis can offer a more accurate characterization of the dopaminergic damage in patients with suspected Parkinson's disease.

Filippi, L., Bruni, C., Padovano, F., Schillaci, O., Simonetti, G. (2008). The value of semi-quantitative analysis of 123I-FP-CIT SPECT in evaluating patients with parkinson's disease. THE NEURORADIOLOGY JOURNAL, 21(4), 505-509.

The value of semi-quantitative analysis of 123I-FP-CIT SPECT in evaluating patients with parkinson's disease

Filippi,L;SCHILLACI, ORAZIO;SIMONETTI, GIOVANNI MARIA EGISTO
2008-01-01

Abstract

123I-FP-CIT SPECT binding to striatal dopamine transporter (DAT) is markedly reduced in patients with Parkinson's disease (PD) and it may also help in identifyng pre-symptomatic nigrostriatal dysfunction in subjects at risk. This study used semi-quantitative analysis of 123I-FP-CIT SPECT to evaluate the possibility of a more extensive and earlier diagnosis of dopaminergic damage. We used qualitative visual assessment and semi-quantitative measures of striatal DAT binding using 123I-FP-CIT SPECT in 154 patients with suspected PD. A control group comprised 18 people age-matched to the PD group whose follow-up disclosed essential tremor. Abnormal striatal 123I-FP-CIT uptake was evident in 134 out of 154 patients (87%). Qualitative visual assessment showed striatal dopaminergic 123I-FP-CIT uptake was significantly reduced in 60.4% (controlateral putamen to the symptoms), in 31.3% (caudate nucleus) and in 8.3% (ipsolateral basal ganglia to the symptoms). Semi-quantitative analysis showed the following results: 32.8%, 50.7% and 16.5% respectively. We compared these two assessments and their correlation with PD clinical progression. At 24 month follow-up, patients with greater dopaminergic damage at semiquantitative analysis showed a more severe motor disability. Our findings indicate that 123-FP-CIT SPECT with semiquantitative analysis can offer a more accurate characterization of the dopaminergic damage in patients with suspected Parkinson's disease.
2008
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/50 - SCIENZE TECNICHE MEDICHE APPLICATE
English
Dopamine transporter; Parkinson's disease; Semiquantitative analysis; SPECT
Filippi, L., Bruni, C., Padovano, F., Schillaci, O., Simonetti, G. (2008). The value of semi-quantitative analysis of 123I-FP-CIT SPECT in evaluating patients with parkinson's disease. THE NEURORADIOLOGY JOURNAL, 21(4), 505-509.
Filippi, L; Bruni, C; Padovano, F; Schillaci, O; Simonetti, Gme
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/41368
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