The simultaneous expression of 19 apoptosis-related genes was analyzed by RNA-protection assay in peripheral blood mononuclear cells of HIV-infected patients before and during successful antiretroviral therapy (ART). After 12 months of therapy, the expression of the pro-apoptotic genes FAS, FAS-L, FAF-1, FADD, CASPASE-8, DR3, TRAIL, TNFR-1, TRADD, and SAX was significantly downregulated with respect to time 0, while that of BCL-2, BCL-XL, and MCL-7 was significantly upregulated. The data suggest that inhibition of cell death in HIV-positive patients under successful therapy is the result of a complex network of multifactor signaling, correlated with both death and survival of lymphocytes.

Balestrieri, E., Grelli, S., Matteucci, C., Minutolo, A., D'Ettorre, G., Di Sora, F., et al. (2007). Apoptosis-associated gene expression in HIV-infected patients in response to successful antiretroviral therapy. JOURNAL OF MEDICAL VIROLOGY, 79(2), 111-117 [10.1002/jmv.20768].

Apoptosis-associated gene expression in HIV-infected patients in response to successful antiretroviral therapy

BALESTRIERI, EMANUELA;GRELLI, SANDRO;MATTEUCCI, CLAUDIA;MINUTOLO, ANTONELLA;VULLO, VINCENZO;FAVALLI, CARTESIO;MACCHI, BEATRICE;
2007

Abstract

The simultaneous expression of 19 apoptosis-related genes was analyzed by RNA-protection assay in peripheral blood mononuclear cells of HIV-infected patients before and during successful antiretroviral therapy (ART). After 12 months of therapy, the expression of the pro-apoptotic genes FAS, FAS-L, FAF-1, FADD, CASPASE-8, DR3, TRAIL, TNFR-1, TRADD, and SAX was significantly downregulated with respect to time 0, while that of BCL-2, BCL-XL, and MCL-7 was significantly upregulated. The data suggest that inhibition of cell death in HIV-positive patients under successful therapy is the result of a complex network of multifactor signaling, correlated with both death and survival of lymphocytes.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/07 - Microbiologia e Microbiologia Clinica
Settore BIO/14
English
Con Impact Factor ISI
AIDS; Antiretroviral therapy; Apoptosis; HIV-1
Balestrieri, E., Grelli, S., Matteucci, C., Minutolo, A., D'Ettorre, G., Di Sora, F., et al. (2007). Apoptosis-associated gene expression in HIV-infected patients in response to successful antiretroviral therapy. JOURNAL OF MEDICAL VIROLOGY, 79(2), 111-117 [10.1002/jmv.20768].
Balestrieri, E; Grelli, S; Matteucci, C; Minutolo, A; D'Ettorre, G; Di Sora, F; Montella, F; Vullo, V; Vella, S; Favalli, C; Macchi, B; Mastino, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/41356
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