Purpose: Capecitabine is a relatively new oral fluoropyrimidine currently licensed for the treatment of colorectal and breast cancer. Results: It has the advantage of oral administration with good tolerability and comparable activity to intravenous 5-fluorouracil. Central neurotoxicity has been described in 5-fluorouracil-treated patients but there is little data regarding capecitabine. We report here a case of reversible capecitabine-induced encephalopathy progressing to coma. Discussion: Literature on fluoropyrimidine-related neurotoxicity will also be reviewed and possible mechanisms of the drug or its metabolites crossing the blood-brain barrier will be discussed.

Formica, V., Leary, A., Cunningham, D., Chua, Y.j. (2006). 5-Fluorouracil can cross brain-blood barrier and cause encephalopathy: Should we expect the same from capecitabine? A case report on capecitabine-induced central neurotoxicity progressing to coma. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 58(2), 276-278 [10.1007/s00280-005-0159-4].

5-Fluorouracil can cross brain-blood barrier and cause encephalopathy: Should we expect the same from capecitabine? A case report on capecitabine-induced central neurotoxicity progressing to coma

Formica, V.;
2006-01-01

Abstract

Purpose: Capecitabine is a relatively new oral fluoropyrimidine currently licensed for the treatment of colorectal and breast cancer. Results: It has the advantage of oral administration with good tolerability and comparable activity to intravenous 5-fluorouracil. Central neurotoxicity has been described in 5-fluorouracil-treated patients but there is little data regarding capecitabine. We report here a case of reversible capecitabine-induced encephalopathy progressing to coma. Discussion: Literature on fluoropyrimidine-related neurotoxicity will also be reviewed and possible mechanisms of the drug or its metabolites crossing the blood-brain barrier will be discussed.
2006
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MEDS-09/A - Oncologia medica
English
Formica, V., Leary, A., Cunningham, D., Chua, Y.j. (2006). 5-Fluorouracil can cross brain-blood barrier and cause encephalopathy: Should we expect the same from capecitabine? A case report on capecitabine-induced central neurotoxicity progressing to coma. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 58(2), 276-278 [10.1007/s00280-005-0159-4].
Formica, V; Leary, A; Cunningham, D; Chua, Yj
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/412324
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