Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases which are involved in the proteolytic processing of several components of the extracellular matrix. As a consequence, MMPs are implicated in several physiological and pathological processes, like skeletal growth and remodelling, wound healing, cancer, arthritis, and multiple sclerosis, raising a very widespread interest toward this class of enzymes as potential therapeutic targets. Here, structure-function relationships are discussed to highlight the role of different MMP domains on substrate/inhibitor recognition and processing and to attempt the formulation of advanced guidelines, based on natural substrates, for the design of inhibitors more efficient in vivo. © 2008 Bentham Science Publishers Ltd.

Aureli, L., Gioia, M., Cerbara, I., Monaco, S., Fasciglione, G., Marini, S., et al. (2008). Structural bases for substrate and inhibitor recognition by matrix metaloproteinases. CURRENT MEDICINAL CHEMISTRY, 15(22), 2192-2222 [10.2174/092986708785747490].

Structural bases for substrate and inhibitor recognition by matrix metaloproteinases

GIOIA, MAGDA;FASCIGLIONE, GIOVANNI;MARINI, STEFANO;COLETTA, MASSIMILIANO
2008-01-01

Abstract

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases which are involved in the proteolytic processing of several components of the extracellular matrix. As a consequence, MMPs are implicated in several physiological and pathological processes, like skeletal growth and remodelling, wound healing, cancer, arthritis, and multiple sclerosis, raising a very widespread interest toward this class of enzymes as potential therapeutic targets. Here, structure-function relationships are discussed to highlight the role of different MMP domains on substrate/inhibitor recognition and processing and to attempt the formulation of advanced guidelines, based on natural substrates, for the design of inhibitors more efficient in vivo. © 2008 Bentham Science Publishers Ltd.
2008
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10 - BIOCHIMICA
English
Con Impact Factor ISI
Enzyme-inhibitor recognition; Enzyme-substrate recognition; Matrix metalloproteinases; Structural bases
Aureli, L., Gioia, M., Cerbara, I., Monaco, S., Fasciglione, G., Marini, S., et al. (2008). Structural bases for substrate and inhibitor recognition by matrix metaloproteinases. CURRENT MEDICINAL CHEMISTRY, 15(22), 2192-2222 [10.2174/092986708785747490].
Aureli, L; Gioia, M; Cerbara, I; Monaco, S; Fasciglione, G; Marini, S; Ascenzi, P; Topai, A; Coletta, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/41210
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