Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases which are involved in the proteolytic processing of several components of the extracellular matrix. As a consequence, MMPs are implicated in several physiological and pathological processes, like skeletal growth and remodelling, wound healing, cancer, arthritis, and multiple sclerosis, raising a very widespread interest toward this class of enzymes as potential therapeutic targets. Here, structure-function relationships are discussed to highlight the role of different MMP domains on substrate/inhibitor recognition and processing and to attempt the formulation of advanced guidelines, based on natural substrates, for the design of inhibitors more efficient in vivo. © 2008 Bentham Science Publishers Ltd.
Aureli, L., Gioia, M., Cerbara, I., Monaco, S., Fasciglione, G.F., Marini, S., et al. (2008). Structural bases for substrate and inhibitor recognition by matrix metaloproteinases. CURRENT MEDICINAL CHEMISTRY, 15(22), 2192-2222.
Tipologia: | Articolo su rivista |
Citazione: | Aureli, L., Gioia, M., Cerbara, I., Monaco, S., Fasciglione, G.F., Marini, S., et al. (2008). Structural bases for substrate and inhibitor recognition by matrix metaloproteinases. CURRENT MEDICINAL CHEMISTRY, 15(22), 2192-2222. |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore BIO/10 |
Revisione (peer review): | Esperti anonimi |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.2174/092986708785747490 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2008 |
Titolo: | Structural bases for substrate and inhibitor recognition by matrix metaloproteinases |
Autori: | |
Autori: | Aureli, L; Gioia, M; Cerbara, I; Monaco, S; Fasciglione, GF; Marini, S; Ascenzi, P; Topai, A; Coletta, M |
Appare nelle tipologie: | 01 - Articolo su rivista |
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Review MMP CMC.pdf | N/A | EmbargoOpen Access Visualizza/Apri |