Several viruses, including influenza, induce an imbalance of intracellular redox state toward pro-oxidant conditions. Through different mechanisms these alterations contribute both to influenza virus replication and to the pathogenesis of virus-induced disease. At the same time, influenza virus activates several intracellular signaling pathways involved in important physiological functions of the cell. Interestingly, many of these pathways are finely regulated by small changes in intracellular redox state, and the virus-induced redox imbalance might also control viral replication through this mechanism. Here we review the main intracellular redox-sensitive pathways activated upon influenza infection and involved in regulating viral replication.

Nencioni, L., Sgarbanti, R., De Chiara, G., Garaci, E., Palamara, A.t. (2007). Influenza virus and redox mediated cell signaling: a complex network of virus/host interaction. NEW MICROBIOLOGICA, 30(4), 367-375.

Influenza virus and redox mediated cell signaling: a complex network of virus/host interaction

GARACI, ENRICO;
2007-01-01

Abstract

Several viruses, including influenza, induce an imbalance of intracellular redox state toward pro-oxidant conditions. Through different mechanisms these alterations contribute both to influenza virus replication and to the pathogenesis of virus-induced disease. At the same time, influenza virus activates several intracellular signaling pathways involved in important physiological functions of the cell. Interestingly, many of these pathways are finely regulated by small changes in intracellular redox state, and the virus-induced redox imbalance might also control viral replication through this mechanism. Here we review the main intracellular redox-sensitive pathways activated upon influenza infection and involved in regulating viral replication.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/07 - Microbiologia e Microbiologia Clinica
English
Con Impact Factor ISI
GSH; Influenza virus; MAPK; Redox state
PMID: 18080671
Nencioni, L., Sgarbanti, R., De Chiara, G., Garaci, E., Palamara, A.t. (2007). Influenza virus and redox mediated cell signaling: a complex network of virus/host interaction. NEW MICROBIOLOGICA, 30(4), 367-375.
Nencioni, L; Sgarbanti, R; De Chiara, G; Garaci, E; Palamara, At
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/41131
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact