The molecular chaperone TRAP1 regulates energy metabolism, and its activity is relevant in cancer and degenerative diseases. Here, Sanchez-Martin et al. identify highly selective allosteric inhibitors of TRAP1. These compounds revert biochemical and pro-neoplastic effects of TRAP1 and could both enlighten its mode of action and disclose novel therapeutic strategies.
Sanchez-Martin, C., Moroni, E., Ferraro, M., Laquatra, C., Cannino, G., Masgras, I., et al. (2020). Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1. CELL REPORTS, 31(3), 107531 [10.1016/j.celrep.2020.107531].
Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1
Carlos Sanchez-Martin;
2020-01-01
Abstract
The molecular chaperone TRAP1 regulates energy metabolism, and its activity is relevant in cancer and degenerative diseases. Here, Sanchez-Martin et al. identify highly selective allosteric inhibitors of TRAP1. These compounds revert biochemical and pro-neoplastic effects of TRAP1 and could both enlighten its mode of action and disclose novel therapeutic strategies.| File | Dimensione | Formato | |
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sanchez-Martin et al cellrep2020.pdf
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