Mucinous carcinoma of the breast, also known as colloid carcinoma, is an uncommon type of differentiated adenocarcinoma, representing only 2% of all invasive breast carcinomas. It usually occurs in women ≥ 60 years of age. Mucinous carcinoma is characterized by clusters of epithelial tumour cells suspended in pools of extracellular mucin and is further divided in 2 subgroups, pure and mixed. Compared to invasive ductal carcinoma, mucinous carcinoma has a better prognosis, being characterized by a lower incidence of nodal involvement and a more favorable histological grade, with low proliferative activity and high expression of hormone receptors. Overall 10-year survival is estimated to be more than 90%. We present a case of a 57-year-old female patient who presented a palpable mass in the right breast for at least 2 years. On examination the whole breast appeared swollen, congestive and painless to palpation. Breast ultrasound, breast MRI and tru-cut biopsy were performed and suggested an advanced infiltrated carcinoma with mucinous aspects. Immunohistochemistry study demonstrated ER positivity (95%), PR low (5%), HER-2-Neu negativity (score 0) and proliferative index (Ki67) of 20%, determining a Luminal B-like (HER 2-negative) subtype. The patient was then candidated to mastectomy surgery and breast reconstruction with DIEP flap. Axillary lymp-nodes were sampled surgically.

Pistolese, C.a., Giuliano, F.d., Cerocchi, M., Volpe, M., Dellanea, M.c., Briganti, F., et al. (2025). Radiological images of an advanced invasive carcinoma with mucinous aspects: a case report. RADIOLOGY CASE REPORTS, 20(3), 1776-1783 [10.1016/j.radcr.2024.12.032].

Radiological images of an advanced invasive carcinoma with mucinous aspects: a case report

Pistolese, Chiara Adriana;Giuliano, Francesca Di;Cerocchi, Martina;Volpe, Maria;Dellanea, Martina Cerasi;Briganti, Flavia;Gigliotti, Paola Elda;Goffredo, Carolina;Giudice, Lucia;Caccia, Diletta;Servadei, Francesca;De Majo, Adriano;Materazzo, Marco;Pistilli, Giorgio;Vanni, Gianluca;
2025-03-01

Abstract

Mucinous carcinoma of the breast, also known as colloid carcinoma, is an uncommon type of differentiated adenocarcinoma, representing only 2% of all invasive breast carcinomas. It usually occurs in women ≥ 60 years of age. Mucinous carcinoma is characterized by clusters of epithelial tumour cells suspended in pools of extracellular mucin and is further divided in 2 subgroups, pure and mixed. Compared to invasive ductal carcinoma, mucinous carcinoma has a better prognosis, being characterized by a lower incidence of nodal involvement and a more favorable histological grade, with low proliferative activity and high expression of hormone receptors. Overall 10-year survival is estimated to be more than 90%. We present a case of a 57-year-old female patient who presented a palpable mass in the right breast for at least 2 years. On examination the whole breast appeared swollen, congestive and painless to palpation. Breast ultrasound, breast MRI and tru-cut biopsy were performed and suggested an advanced infiltrated carcinoma with mucinous aspects. Immunohistochemistry study demonstrated ER positivity (95%), PR low (5%), HER-2-Neu negativity (score 0) and proliferative index (Ki67) of 20%, determining a Luminal B-like (HER 2-negative) subtype. The patient was then candidated to mastectomy surgery and breast reconstruction with DIEP flap. Axillary lymp-nodes were sampled surgically.
mar-2025
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MEDS-04/A - Anatomia patologica
English
BIRADS
Breast MRI
Breast biopsy
Breast cancer
Mucinous carcinoma
Surgery
Pistolese, C.a., Giuliano, F.d., Cerocchi, M., Volpe, M., Dellanea, M.c., Briganti, F., et al. (2025). Radiological images of an advanced invasive carcinoma with mucinous aspects: a case report. RADIOLOGY CASE REPORTS, 20(3), 1776-1783 [10.1016/j.radcr.2024.12.032].
Pistolese, Ca; Giuliano, Fd; Cerocchi, M; Volpe, M; Dellanea, Mc; Briganti, F; Gigliotti, Pe; Goffredo, C; Giudice, L; Caccia, D; Servadei, F; De Majo...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/408724
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