PURPOSE: To investigate the efficacy of reducing the drop-skin contact to prevent dermatologic side effects of bimatoprost 0.03% topical therapy. DESIGN: Prospective, randomized, single-blinded, internally controlled study. METHODS: Enrolled subjects started bimatoprost 0.03% therapy once at night in both eyes and were instructed to wipe selectively only one eye (eye 1) with an adsorbent pad during and after drops administration for four months. The fellow eye acted as the internal control. Eyelash growth, regional skin hypertrichosis, and pigmentation on the periocular skin were assessed at baseline and during the four months of follow-up. RESULTS: A lower incidence of eyelash growth and skin pigmentation in the inferonasal pericanthal region were observed in eye 1. The incidence of pigmentation in the inferotemporal skin region and skin hypertrichosis were similar in the two eyes. CONCLUSION: The reduction of the drop,skin contact affects the regional incidence and the extent of dermatologic skin changes that are related to bimatoprost 0.03% topical therapy.

Centofanti, M., Oddone, F., Chimenti, S., Tanga, L., Citarella, L., Manni, G. (2006). Prevention of Dermatologic Side Effects of Bimatoprost 0.03% Topical Therapy. AMERICAN JOURNAL OF OPHTHALMOLOGY, 142(6), 1059-1060 [10.1016/j.ajo.2006.07.019].

Prevention of Dermatologic Side Effects of Bimatoprost 0.03% Topical Therapy

CENTOFANTI, MARCO;CHIMENTI, SERGIO;MANNI, GIANLUCA
2006-01-01

Abstract

PURPOSE: To investigate the efficacy of reducing the drop-skin contact to prevent dermatologic side effects of bimatoprost 0.03% topical therapy. DESIGN: Prospective, randomized, single-blinded, internally controlled study. METHODS: Enrolled subjects started bimatoprost 0.03% therapy once at night in both eyes and were instructed to wipe selectively only one eye (eye 1) with an adsorbent pad during and after drops administration for four months. The fellow eye acted as the internal control. Eyelash growth, regional skin hypertrichosis, and pigmentation on the periocular skin were assessed at baseline and during the four months of follow-up. RESULTS: A lower incidence of eyelash growth and skin pigmentation in the inferonasal pericanthal region were observed in eye 1. The incidence of pigmentation in the inferotemporal skin region and skin hypertrichosis were similar in the two eyes. CONCLUSION: The reduction of the drop,skin contact affects the regional incidence and the extent of dermatologic skin changes that are related to bimatoprost 0.03% topical therapy.
2006
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/30 - MALATTIE APPARATO VISIVO
English
Con Impact Factor ISI
adsorbent; bimatoprost; adult; aged; article; clinical article; clinical trial; controlled clinical trial; controlled study; drug efficacy; eyelash; eyelash growth; female; follow up; glaucoma; hair disease; hair growth; human; hyperpigmentation; hypertrichosis; incidence; intraocular hypertension; male; outcome assessment; parallel design; priority journal; prophylaxis; prospective study; randomized controlled trial; side effect; single blind procedure; skin toxicity; topical treatment; Adult; Aged; Amides; Antihypertensive Agents; Cloprostenol; Disposable Equipment; Eyelashes; Eyelid Diseases; Female; Glaucoma; Hair Diseases; Humans; Hyperpigmentation; Intraocular Pressure; Lipids; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Ophthalmology; Prospective Studies; Single-Blind Method; Skin Care; Skin Pigmentation
Centofanti, M., Oddone, F., Chimenti, S., Tanga, L., Citarella, L., Manni, G. (2006). Prevention of Dermatologic Side Effects of Bimatoprost 0.03% Topical Therapy. AMERICAN JOURNAL OF OPHTHALMOLOGY, 142(6), 1059-1060 [10.1016/j.ajo.2006.07.019].
Centofanti, M; Oddone, F; Chimenti, S; Tanga, L; Citarella, L; Manni, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/40822
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